What is the relationship between Prozac and GERD? 

In this blog post, we are going to talk about the relationship between Prozac, an antidepressant, and gastroesophageal reflux disease (GERD). Prozac is associated with a number of side effects, ranging from mild to severe. 

What is the relationship between Prozac and GERD?

Prozac and GERD have a negative relationship because prozac induced acid reflux can exacerbate the symptoms of GERD. Although the drug itself does not possess anticholinergic effects which cause malfunctioning of esophageal sphincter muscle, which is the main cause of GERD. 

What are the symptoms associated with GERD? 

GERD or gastroesophageal reflux disease is an entire medical condition in itself. It is not just a case of increased acidity after you eat spicy food or have an upset stomach, it’s actually a disease. It is caused when prolonged acid reflux damages the sphincter of the oesophagus. 

This allows the acid to reach your throat and cause disturbing side effects which include:

  • Damage to esophageal mucosa
  • Swelling or pain in throat 
  • Burning sensation in mouth, throat, chest and stomach. 
  • Inability to digest food
  • Difficulty in swallowing food
  • Blisters in mouth
  • Lump-in-throat feeling
  • Stomach ulcer
  • Cough
  • Difficulty in breathing
  • Highly acidic vomiting, which further damages the upper gastrointestinal tract. 

GERD, as you can see from the side effects, is a disturbing condition. Experts believe that it can attack a certain variety of individuals more often as compared to other people. These people are also more susceptible to prozac induced increased stomach acidity. These people include:

  • People who are obese are more likely to suffer from this condition. Several studies suggest excess belly fat can result in GERD like symptoms. 
  • People living with underlying conditions like hiatal hernia. 
  • Pregnant women 
  • People who have prolonged gastric emptying time
  • Smoking
  • Heavily spiced and oily food
  • Overeating, which leads to higher gastric acid production in order to digest the excess amount of food.

How can you relieve the symptoms associated with GERD while being on Prozac? 

Severe GERD in the presence of prozac can cause disturbing complications. There are a few things you can try to help relieve the symptoms of GERD. These include:

Visit your healthcare professional 

First thing’s first, tell your doctor about your side effects. It is extremely important to discuss if it’s okay to continue using prozac. If your side effects decrease the quality of your life, it simply means you need to change your antidepressant or reduce the dose. 

Prozac is meant to be taken daily and for a couple of months, depending on your condition. If it’s not comfortable, it can’t be tolerated well. Yes, it will produce side effects, but these side effects begin to subside within a few weeks of your treatment. 

If your side effects persist, it means prozac is not the right choice of antidepressant for you. 

What is the relationship between Prozac and GERD? 

Avoid taking prozac on an empty stomach 

If you suffer from prozac induced GERD like side effects, it is important to make sure you don’t take your med on an empty stomach. The drug itself increases the acid content of the stomach because of the nature of its formulation. 

Without food, it directly affects gastric mucosa, which is the protective membrane lining your stomach. Make sure you eat something before taking your prozac or try taking it with meals. 

Don’t eat too much carbs

Some researchers suspected that undigested carbs may cause bacterial overgrowth and increased pressure inside the abdomen, which could contribute to acid reflux. Having high amounts of undigested carbs in your stomach can cause flatulence and bloating. 

Avoid bad eating habits 

Do not eat heavy meals 3 hours before bedtime. When you lie down on bed, the process of digestion gets slower. So you need to digest your food before you go to sleep. 

Avoid eating large portions of food. You can try having smaller, more frequent meals. Large meals can put a burden on your stomach and it releases more and more acid to help digest the food. 

Avoid drinking carbonated beverages 

Studies have observed that regular consumption of carbonated or fizzy beverages, including soft drinks, club soda, and seltzer, could be linked to a higher risk of gastric esophageal reflux. 

One study found that carbonated soft drinks can worsen certain acid reflux symptoms, like heartburn, fullness, and burning sensation in your throat. 

This is because carbonated beverages make your burp more, that can increase the amount of acid escaping your stomach and irritating your oesophagus, throat and mouth. 

Walk a mile after dinner

Studies suggest that going for a short walk after dinner can help your body to produce more digestive enzymes and makes your stomach absorb the nutrients from your food. 

It improves your digestion and reduces bloating, acid reflux, constipation and provides relaxation from several other gastrointestinal problems. 

Add natural probiotics to your diet

Milk and yoghurt are considered natural probiotics. They are well known to provide relief from gastric acidity. Yoghurt contains lactobacillus, also known as ‘good bacteria’. This good bacteria can improve your digestion and can manage excessive acid secretion in your stomach. 

Cut back on spicy foods

Heavily spiced food is your biggest enemy when it comes to coping with gastric acid reflux. Spicy food can mess up your stomach and is the most common cause of acid reflux in people who add high amounts of spices in their foods. Make sure you cut back on spicy food, at least for a while. 

Try Over-the-counter acid reducers 

You can also try OTC medications to help relieve the symptoms of GERD. Make sure you ask for your doctor’s approval first to rule out any drug interaction. 

Antacids are widely used to relieve heartburn. They are alkaline in nature and once inside your stomach, they neutralise gastric acid. Examples include Aluminium hydroxide gel (Alternagel), calcium carbonate (Alka-Seltzer), gaviscon, pepto-Bismol etc. 

Histamine-2-blockers are also used to relieve heartburn. These OTC meds inhibit the production of gastric acid. Examples include cimetidine, famotidine, rimantadine, zantac 360 and nizatidine etc. 

Proton pump inhibitors or PPIs are also used to inhibit stomach acid secretion. These meds are used worldwide to treat heartburn and indigestion. Examples include lansoprazole (Prevacid), esomeprazole (Nexium), and omeprazole (Risek)

Other drugs which can exacerbate the symptoms of GERD

There are several other medications that can make your GERD even more unbearable. These include:

  • Antibiotics are well known for upsetting your stomach. They can kill natural gut microflora and make your GERD much worse. 
  • Supplements to replenish iron reserves 
  • Antimalarial agents
  • Non-steroidal anti-inflammatory drugs (NSAIDS)*
  • Anticholinergic drugs
  • Antihypertensives, like calcium channel blockers, beta blockers and ACE inhibitors. 
  • Controlled substances including narcotic analgesics, amphetamines, ecstasy etc. 
  • Certain hormones like progesterone. 
  • Sedatives and hypnotics

*Note: NSAIDS are not safe to be used with prozac. The concomitant use can increase the risk of bleeding. 

Make sure you tell your healthcare provider about your side effects and ask if there’s any other prescription medication that might exacerbate the symptoms of GERD, all on its own or in combination with prozac. It is important to be safe from disturbing drug interactions.

Make sure you’re using prozac properly, to take the maximum benefits from the antidepressant. If you fail to understand how to use the drug properly or have any other question, ask your doctor or pharmacist. In case of overdose, immediately reach out to the hospital. 

Make sure you properly guide them about how much drug you have taken and when. If you have missed a dose and you’re way past the usual time at which you take your med, do not take it. It will cause you to overdose when you take your next dose, which is not too far away. 

It’s better to skip the missed dose and take the next one. If you remember your missed dose earlier, it’s safe for you to take it.


In this blog, we talked about the relationship between Prozac and GERD. Prozac is known to increase stomach acidity and cause disturbing gastrointestinal side effects. Prolonged use of prozac can damage your stomach lining and cause gastroesophageal reflux. 

The main cause of GERD is known to be the malfunctioning of the esophageal sphincter, which is made up of muscles. These muscles are badly damaged as a result of prolonged acid reflux. 

Take your Prozac with meals. Adopt a healthy lifestyle, add loads of probiotics in your diet and avoid stomach irritants, as long as you suffer from this problem. It is best to discuss with your healthcare provider the types of OTC acid reducers which are safe to use and if there is any dose adjustment required.

FAQs: prozac and GERD

Is fluoxetine good for GERD? 

Fluoxetine may help to reduce the symptoms associated with gerd by enhancing the effects of esophageal sphincter. The main cause of GERD is known to be the malfunctioning of the esophageal sphincter, which is made up of muscles.

Can antidepressants make acid reflux worse?

Yes, antidepressants are indeed capable of making your acid reflux worse. However, this side effect seems to tone down a bit if you take your antidepressant with food. Studies suggest that taking your prozac on an empty stomach makes you more susceptible to acid reflux. There are also plenty of other tips that can help you manage your acidity. 

Can Prozac cause digestive issues?

Prozac can cause digestive issues and gastrointestinal side effects including nausea, vomiting and diarrhoea. It can also cause acid reflux, which may make you go through swelling in your throat muscles or lump-in-throat feeling. Make sure you report to your healthcare provider if you exhibit any serious side effects. 

Can Prozac increase acid reflux?

Yes, prozac can increase acid reflux. In fact, this is one of the most commonly reported side effects induced by prozac. However, some case studies revealed an extreme heartburn, which led to the discontinuation of treatment with this antidepressant. 

Can antidepressants cause heartburn?

Yes, antidepressants can cause heartburn associated with increased stomach acidity. However, this side effect seems to tone down a bit if you take your antidepressant with food. Studies suggest that taking your prozac on an empty stomach makes you more susceptible to acid reflux. 

Can SSRIs cause GERD?

SSRIs can cause GERD-like symptoms because of its ability to increase stomach acid secretion and acidic reflux. Although the drug itself does not possess anticholinergic effects which cause malfunctioning of esophageal sphincter muscle, it can definitely increase stomach acidity and exacerbate the symptoms of pre-existing GERD.