What are the benefits of combining Wellbutrin and Zoloft? 

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Page last updated: 4/10/2022

There are a number of benefits of combining Wellbutrin and Zoloft. Some of these include:

  • Better management of major depressive disorder (MDD) 
  • Fewer Zoloft-induced sexual side effects 
  • Increased energy and motivation 
  • Fewer chances of gaining weight as a side effect 
  • Low doses are enough to achieve a good therapeutic response 

Better management of major depressive disorder (MDD)

The combination of Wellbutrin and Zoloft can be used for the safe and effective treatment of MDD. Major depressive disorder is not the usual kind of depression that starts to get better with monotherapy. 

This type of depression is extremely persistent in nature and it only responds to a good combination of compatible antidepressants. That’s where Wellbutrin and Zoloft come into the picture. 

Together these two well-known antidepressants can provide a broader spectrum of antidepressant effects and increase the quantity and functions of three different excitatory monoamine neurotransmitters; serotonin, norepinephrine, and dopamine. 

These three neurotransmitters are closely related to the symptoms associated with depression and a number of other mental health-related problems. 

Fewer Zoloft-induced sexual side effects 

Zoloft is a selective serotonin reuptake inhibitor (SSRI) and the antidepressants belonging to the class are well-known for causing sexual side effects. Some of these include:

  • Loss of sexual desire in both men and women 
  • Inability to ejaculate and erectile dysfunction in men
  • Inability to achieve an orgasm in women

These side effects are actually quite common with Zoloft and are reported by a huge number of people. However, the combination of Wellbutrin and Zoloft has a lesser incidence of such side effects. 

This is because Wellbutrin is not associated with any kind of sexual side effect and it somehow protects you from Zoloft-induced sexual side effects as well. That enhances patient compliance and people don’t feel that sexually irritated while being treated with this combination.

Increased energy and motivation

The combination of Wellbutrin and Zoloft can help increase your energy levels. This is because of the energy-boosting nature of Wellbutrin. It is considered the best antidepressant for energy and motivation. 

There are a huge number of research studies that have proved this beneficial effect of Wellbutrin. As the combination of Wellbutrin and Zoloft is tolerated well, it can be a good treatment regimen for the management and treatment of MDD comorbid with chronic fatigue. 

Fewer chances of gaining weight as a side effect 

The combination of Wellbutrin and Zoloft has fewer chances of causing weight gain as a side effect, which is a common problem among people who use antidepressants. If we particularly look at Zoloft, this antidepressant is associated with weight gain as a side effect if used individually. 

It can increase your appetite and slow down your metabolism. This can make you gain a significant amount of weight. However, Wellbutrin is quite the opposite. 

It is considered one of the best antidepressants, in fact, the best antidepressant for weight loss. Wellbutrin monotherapy has been helping people who suffer from depression comorbid with obesity for decades. 

The combination of Wellbutrin and Zoloft can help prevent Zoloft-induced weight gain on one hand and may help you lose some of the extra weight on the other hand. However, if you’re at your ideal weight, you may not lose or gain weight at all. 

Low doses are enough to achieve a good therapeutic response 

The combination of Wellbutrin and Zoloft does not need high doses to make significant changes. This is because when you’re using a single antidepressant, that med is solely responsible for making changes in your mental health condition. 

It may take too long on a low dose to work and if you take a higher one, your body may not be able to tolerate the side effects that will come with it. This is why a combination of antidepressants can work wonders on your body, especially in the case of MDD. 

Most healthcare providers prescribe doses much lower than the standard doses of each of the drugs when used individually. This can reduce the incidence of side effects and help you recover in a safe and effective manner. 

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