5 Wellbutrin side effects (BUPROPION)

Wellbutrin (bupropion) is a medication that treats a variety of conditions.

It comes as immediate-release, sustained-release, or an extended-release pill that’s taken orally. 

One issue that makes Wellbutrin particularly distinctive among antidepressants is that it does not tend to affect your sexual desire and sexual performance.

It’s usually prescribed in conjunction with different antidepressants to assist to counter the sexual side effects found in different varieties of antidepressant medications.

That said, Wellbutrin in any kind is not without side effects, a number of them are serious.

If your doctor prescribes Wellbutrin for you, it is vital to remember what symptoms you can and do experience.

Some side effects are simply pestering and can disappear as your system gets accustomed to the medication, however, others could also be serious and may prompt you to notify your doctor quickly to allow them to know that you are having issues.


Wellbutrin is approved by the Food and Drug Administration (FDA) to treat major depressive disorder (MDD) and seasonal emotional disorder (SAD).

Off-Label Uses

Wellbutrin is additionally used off-label to assist with symptoms of attention-deficit/hyperactivity disorder (ADHD), manic-depressive psychosis, anxiety, and avoirdupois.

Another use of bupropion (the active ingredient in Wellbutrin) known as Zyban is employed to assist people to quit smoking.

Other off label uses typically involve social psychological disorder, PTSD, and even some kinds of nerve pain.

Before Taking

Wellbutrin is usually used as a first-line medication within the treatment of major emotional disturbance and seasonal affective disorder.

Your doctor can evaluate your symptoms and current health standing to work out if Wellbutrin is correct for you.

Other Norepinephrine-dopamine Uptake Inhibitors

Among antidepressants, bupropion is in a very class all its own—it’s the sole medication in its category, known as norepinephrine-dopamine reuptake inhibitors (NDRIs), that reinforces the neurotransmitters noradrenaline and Dopastat.

By distinction, selective 5-hydroxytryptamine reuptake inhibitors (SSRIs) like selective-serotonin reuptake inhibitors (fluoxetine) and selective-serotonin reuptake inhibitor (sertraline) affect serotonin, whereas 5-hydroxytryptamine and noradrenaline reuptake inhibitors (SNRIs) like Cymbalta (duloxetine) and Effexor (venlafaxine) boost noradrenaline and 5-hydroxytryptamine.


Wellbutrin contains chemicals known as aminoketones and comes in three different versions: immediate release, sustained release, and extended. Dosing varies for every version:

Ø  Immediate release: The regular formulation, simply named Wellbutrin, is an immediate release medication, which suggests that it begins to affect you shortly once you’re taking it. As a result of it acting quickly, it may be taken a few times daily. This formulation is employed to treat the major emotional disorder (MDD). A beginning dose is sometimes 100mg taken twice daily and sometimes increased to 100mg taken three times daily. The largest suggested dose is 150mg per single dose.

Ø  Sustained release: Wellbutrin SR, the sustained release version, also treats MDD. This formulation is usually started at 150mg once daily and is sometimes increased to 150mg twice daily. It may be increased to at most 200mg taken twice daily.

Ø  Extended release: Taken once daily, Wellbutrin XL is employed to treat MDD and to forestall seasonal major affective disorder (SAD). It’s usually taken as a dose of 150mg once daily and may be increased to 300mg or maybe 450mg at most, each taken once daily.


In some cases, your doctor could decide to give you a changed dose of the drug in accordance to potential side effects or other various health concerns.

Ø  With liver impairments: The dose is usually decreased to doses of 75mg per day for those with moderate to severe liver impairment.

Ø  With urinary organ problems: Your doctor might also lower your dose or the frequency of use if you’ve got urinary organ impairments.

Ø  Whilst or before taking MAOIs: If you have previously taken an MAO substance (MAOI) or are thinking about taking an MAOI, you must wait fourteen days between the ending of your previous drug and the initiation of your new MAOI treatment.

How to Take and Store

You should always take your medication as directed. Immediate release Wellbutrin tablets may be broken if necessary, however, they’re sufficiently small enough that’s not typically required.

The drug may be taken either on an empty stomach or with food.

Your medication must be stored at room temperature and guarded from sunlight and wetness.

If you happen to miss a dose of bupropion, take it as soon as you realize you missed a dose.

Any remaining doses for the day ought to be taken a minimum of four hours apart.

Never take 2 doses right away to make up for a missed dose.

Taking 2 doses at the same time will increase your risk of experiencing a seizure or accidental overdose.

Side Effects


Side effects could occur however the likelihood that a side effect could occur typically decreases after your body has adjusted to the medication.

The foremost common side effects for Wellbutrin instant release, Wellbutrin sustained release, and Wellbutrin extended release include:

Ø  Constipation

Ø  Giddiness

Ø  Nervousness

Ø  Dehydration

Ø  Changes food tastes

Ø  Headache

Ø  Exaggerated sweating

Ø  Tremors

Ø  Nausea

Ø  Vomiting

Ø  Anxiety

Ø  Restlessness

Ø  Insomnia

Ø  Weight loss

Ø  Joint aches

Ø  Appetite loss

Ø  Flushing

Ø  Gas

Ø  Urinating more than usual

Ø  Ringing in your ears

Ø  Abdominal pain

Ø  Hair loss

Ø  Weakness


Some side effects of Wellbutrin could be very severe and in rare cases may lead to death.

Seek medical attention quickly if you experience any of the following side effects while taking any version of Wellbutrin: 

Ø  Skin rash; hives; itching; problem breathing; a sense of tightness in your chest; swelling of your mouth, face, or tongue; and/or uncommon gruffness, all signs that you just could also be having a strong allergy to the drug

Ø  Changes in vision

Ø  Changes in desire or perform

Ø  Pain

Ø  Confusion

Ø  Dark tinkle

Ø  Delusions or hallucinations

Ø  Fainting

Ø  Fast or irregular heartbeat

Ø  Fever, chills, or a raw throat

Ø  Hearing issues

Ø  Changes in your menstrual cycle

Ø  Worsening depression and/or unsafe thoughts

Ø  Exaggerated feelings of well-being

Ø  Trouble concentrating

Ø  Panic attacks

Ø  Aggressiveness or rage episodes

Ø  Hostility

Ø  Agitation

Ø  Inability sit still

Ø  Pale-colored stools

Ø  Swollen, blistered, or peeling skin

Ø  Seizures

Ø  Severe headache

Ø  Severe or lingering joint or muscle pain

Ø  Severe or lingering nausea, vomiting, or abdomen pain

Ø  Severe or lingering nervousness, restlessness, or sleep disorder

Ø  Problem respiratory

Ø  Uncommon swelling

Ø  Yellow skin or eyes


There are a variety of potential interactions that may occur once different substances are taken at the same time as Wellbutrin.

Different medications could influence how bupropion works or increase the danger of side effects.

These include:

Ø  MAO inhibitors (MAOIs)

Ø  Different antidepressants as well as selective-serotonin reuptake inhibitor (fluoxetine), selective-serotonin reuptake inhibitor (sertraline), and Effexor (venlafaxine)

Ø  Antipsychotics like Risperdal (risperidone) or haloperidol (haloperidol)

Ø  Corticosteroids as well as Meticorten

Ø  Blood thinners

Ø  Adderall (amphetamine and dextroamphetamine)

Ø  Thyroid medications like Synthroid (levothyroxine)

Ø  unlisted pain relievers like nonsteroidal anti-inflammatory drug

Ø  polygenic disease medications as well as metformin (metformin)

Ø  Using Wellbutrin with alcohol might also influence the frequency and severity of side effects, as well as seizures and unsafe thoughts.

Wellbutrin Side Effects: Anger and Hostility

Occurrences of Wellbutrin side effects are few, but they still happen, and one of them is anger and hostility, which may manifest in the form of agitation, irritability or just generally angry and abnormal behaviors. Apart from anger and hostility, someone on Wellbutrin may also sometimes experience suicidal thoughts and tendencies, and in some cases, this medicine may worsen depression.


Ø  Seizures and unsafe thoughts are two of the foremost serious potential side effects of Wellbutrin. Seizures are rare with this drug, however, do remember that the danger of seizures is much larger with Wellbutrin than with different antidepressants. For that reason, it’s particularly necessary to let your doctor know if you’ve have or have had a seizure disorder; you’re taking the other medications that contain bupropion, like Zyban (for quitting smoking); otherwise, you have or have had associate upset like eating disorder or bulimia, as seizures area unit additional seemingly to occur with these disorders.

Ø  If you have a child taking Wellbutrin or another medication for treating depression, keep a close eye out for signs of self-harm or suicidal thinking.

Managing Side Effects

Check-in with your doctor regarding any side effects you are experiencing with Wellbutrin if they are severe, bothersome, get worse, or do not depart.

Again, the most common side effects are not very serious and usually are temporary.

Get medical attention quickly if you’ve got any side effects that might be serious or grave.

In either case, do not stop taking Wellbutrin until you have checked with your doctor.

Going full-stop off of any medication will cause your symptoms to come back or even get worse.

Stopping short can also lead to discontinuation syndrome, an associated array of flu-like symptoms like upset stomach, headache, strange sensations, and muscle aches.

If you wish to stop taking Wellbutrin, your doctor can guide you in bit by bit weaning off of it.

Precautions and Contraindications

Your doctor might not prescribe this drug if you have a history of certain health conditions.

Ø  You ought to not take Wellbutrin if you have acute glaucoma or a seizure disorder.

Ø  Individuals with manic-depressive psychosis could also be at associate exaggerated risk of experiencing wild, mixed, or hypomanic episodes once taking Wellbutrin. Whereas bupropion is typically prescribed off-label to treat depressive episodes, it’s not approved for the treatment of bipolar depression. Those with manic-depressive psychosis might also have an exaggerated risk of experiencing unsafe thoughts while taking Wellbutrin.

Ø If you have a history of urinary organ issues, renal disorder, or liver issues, your doctor should suggest a reduced dose of the drug.

Ø  Never take Wellbutrin if you have a known allergic reaction or hypersensitivity to bupropion. You ought to contact emergency services right away if you start to experience allergic reaction symptoms like rash, swelling, hives, itching, and respiratory issues.

Ø  The drug shouldn’t be utilized by women who are breastfeeding or by children.

Wellbutrin could be a class C maternity drug, which means that it’s been shown to have adverse impacts on the fetus in animal studies which are conducted to figure out the effect that the drug may possibly have in humans.

For this reason, the drug should only be used throughout pregnancy if your doctor has determined that the potential advantages outweigh the risks.

Frequently Asked Questions

How long will it see Wellbutrin to kick in?

How long will it take for Bupropion to Work?

While one is in a depressed mood and has a lack of interest in activities, it may take up to 4-6 weeks to show the effects.

Disturbances in sleep, energy, or craving could show some improvement among the first one to two weeks.

Does Wellbutrin affect serotonin?

Most antidepressants are selective monoamine neurotransmitter reuptake substances (SSRI).

They boost the amount of monoamine neurotransmitters within the brain.

Bupropion, or Wellbutrin, is completely different.

It’s a norepinephrine-dopamine reuptake substance (NDRI).

How will Wellbutrin cause you to feel?

Side effects with bupropion are typically rare and if they occur they often resolve after the first one to two of treatment as you continue to take the medication.

The most prominent and frequently experienced side effects of bupropion are: headache, weight loss, dry mouth, trouble sleeping, nausea, dizziness, constipation, quick heartbeat, and sore throat.

Readings of Related Interest:

The New Anti Depressants and Anti Anxieties: What You Need to Know About Zoloft, Paxil, Wellbutrin, Effexor, Clonazepam, Ambien, and More, William S. Appleton

Depression Risk Factors: Beat It Before It Starts, Fight It Once It Does, James Bogash

Wellbutrin (Bupropion): Treats Depression and Aids in Quitting Smoking; also Prevents Depression caused by Seasonal Affective Disorder (SAD), James Lee Anderson


1.     https://www.rxlist.com

2.     https://www.webmd.com/

3.     https://www.drugs.com

4.     https://www.verywellmind.com/