Trazodone Side effects (A complete guide)

In this blog, we will discuss Trazodone side effects, the most common uses of Trazonde, side effects, precautions, potential interactions with other drugs and substances

Trazodone Side effects

The most common side effects of trazodone include: headaches, muscle aches, nausea, vomiting, loss of appetite or weight gain, stomachache, constipation or diarrhea among others. 

At first it might sound a bit daunting and scary right?

Why should you take a drug that instead of making you feel better, if will make you feel worse?

Well, remember that not everyone reacts to certain medication the same way, everyone can experience slightly different side effects but if you are considering taking Trazodone it is important to consider a few things we will discuss next. 

What is Trazodone?

Trazodone is considered an antidepressant drug that belongs to the group of Serotonin Reuptake Inhibitors or SSRIs.

It is used frequently as a treatment for depression. 

This drug was developed in Italy in the 1960s as antidepressant medication.

Initially, due to the side effects, this antidepressant wasn’t widely accepted in the medical community, however, it became recognized by many internists and clinicians because of the potential benefits of the drug, especially when administered at low doses.

Under the name trazodone (generic) in 1981, it was approved by the U.S Food and Drug Administration (FDA) under the brand name Desyrel.

Today, it is prescribed under the brand name Olepro to treat sleep disorders such as insomnia as well as anxiety disorder and unibipolar depression.

Trazodone Side effects (A complete guide)

Does trazodone cause sleepiness?

For many people, this drug has a sedative effect that causes a relaxing effect and can make you feel very sleepy.

In prescribing the drug for sleep disorders, physicians typically recommend taking a low dose at bedtime in order to limit the effects of drowsiness.

Still, some people report lingering effects, including sluggishness and feeling drained or low energy, particularly upon waking.

How does Trazodone work?

Trazodone is meant to restore the depleted chemicals in the brain (neurotransmitters).

One of the most important neurotransmitters is serotonin which when balanced, improves your mood, appetite, memory, sexual function and desire, energy levels, decreases anxiety and insomnia related to depression.

Researchers have found that depression is caused by an imbalance among the neurotransmitters acetylcholine, norepinephrine, dopamine, and serotonin.

It is believed that trazodone affects the brain’s neurotransmitters by inhibiting the uptake of serotonin by nerves and consequently, the increase of this neurotransmitter end up stimulating other nerves.

How quickly does it work?

Some people who use this drug for sleep disorders have indicated that they get to experience the sedative effect within 30 mins after the intake, but remember that every person can react differently to the drug.

People who take it as an antidepressant may start noticing benefits after 1 or 2 weeks of consistently taking the medicine, and it may even take up to 4 weeks to experience the full benefits and desired results. 

Trazodone Side effects (A complete guide)

How should I take it?

The initial dose is usually reported as 150 mg orally per day in divided doses.

This may be increased by 50 mg orally per day every 3 – 4 days.

The maximum dose reported for inpatients is 600 mg a day and for outpatients is 400 mg a day.

Administration

Trazodone’s strengths are as follows:

– 50 mg

– 100 mg

– 150 mg

– 300 mg

The tablets can be swallowed whole or taking it as a half tablet by breaking it along the scoreline.

The tablets should not be chewed or crushed. 

When will I see results?

It can take up to 2 weeks before you start seeing improvement.

If your symptoms are not improving, do not stop the medication and talk to your doctor about it because you could have some unpleasant withdrawal symptoms. 

Trazodone Side effects (A complete guide)

What happens if I miss a dose?

If you miss a dose, take the missing dose as soon as you remember.

If it is almost time to take the next scheduled dose, discard the missing dose and keep taking it as usual.

Do not take an extra or doubled dose to compensate. Neither leave the drug on your own, abruptly because this might lead to Trazodone withdrawal.

What happens if I overdose?

If you overdose with Trazodone, seek immediate medical attention.

An overdose can be fatal if it is combined with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include:

  • Extreme drowsiness
  • Vomiting
  • Prolonged and painful penis erection
  • Faster heartbeats
  • Seizures 
  • Breathing that is slow or stops

Symptoms of an allergic reaction

Trazodone allergic reactions need medical assistance.

If you are experiencing the following symptoms while taking Trazodone, it is very likely that you are allergic to it:

  • Hives
  • Difficulty breathing
  • Swelling of your face, lips, tongue or throat

Trazodone side effects

Report to your doctor any sudden changes related to your mood or behavior, as being impulsive, aggressive, restless, feeling irritable, increased anxiety, panic attacks, trouble sleeping or if you are feeling agitated, hyperactive, even more depressed than before or if you are having suicidal thoughts or wanting to hurt yourself. 

Moreover, if you have shortness of breath, faster or slower heartbeats, sudden dizziness, easy bruising or unusual bleeding; low levels of sodium in your body that will manifest in headaches, confusion, slurred speech, feeling fatigued, vomiting, loss of coordination or feeling unsteady. 

Serotonin syndrome

Serotonin syndrome (SS) happens when certain drugs (antidepressants), being taken 2 or more at a time, that have the purpose of affecting the neurochemistry of the brain (synaptic serotonin levels) cause a severe and toxic interaction. Symptoms may include:

  • Hallucinations
  • Fever
  • Sweating
  • Overactive reflexes
  • Fainting
  • Shivering
  • Faster heart rate
  • Muscle stiffness
  • Twitching
  • Loss of coordination
  • Nausea
  • Vomiting
  • Diarrhea

Common Trazodone side effects

The common side effects of Trazodone intake may include:

  • Drowsiness
  • Dizziness
  • Tiredness
  • Swelling
  • Weight loss
  • Blurred Vision
  • Diarrhea
  • Constipation
  • Stuffy nose
  • Headaches
  • Nausea
  • Vomiting
  • Dry mouth

Other Trazodone side effects

  • Temporary loss of consciousness
  • Swelling 
  • Loss of control of your movements
  • Confusion
  • Diarrhea
  • Hypotension
  • Insomnia
  • Sedated state
  • Faster heart beating

Less common Trazodone side effects 

  • Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • Confusion about identity, place, and time
  • Decreased concentration
  • Fainting
  • A general feeling of discomfort or illness
  • Headache
  • Lack of coordination
  • Muscle tremors
  • Nervousness
  • Pounding in the ears
  • Shortness of breath
  • Slow or fast heartbeat
  • Swelling

Trazodone Drug interaction

There are many drugs that can interact with Trazodone, especially:

  • Any other antidepressant
  • Anagrelide
  • Droperidol
  • Methadone
  • Ondansetron
  • Antibiotics such as azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine
  • Cancer medicine such as arsenic trioxide, vandetanib
  • Anti-malaria medication such as chloroquine, halofantrine
  • Heart rhythm medicine such as amiodarone, disopyramide, dofetilide, dronedarone, flecainide,  ibutilide, quinidine, sotalol
  • Medicine to treat a psychiatric disorder such as chlorpromazine, haloperidol, pimozide, thioridazine.
  • Phenytoin
  • St John’s wort
  • Tramadol
  • Diuretic or “water pill”
  • Anti-anxiety medication
  • Other drugs to treat mood disorders or other mental illnesses such as schizophrenia
  • Blood thinners such as warfarin, coumadin, and jantoven
  • Migraine headache medicine such as sumatriptan, imitrex, maxalt, treximet, among others

This is not a complete list of the drugs that can interact with Trazodone for more information about additional drugs that may interact ask your doctor. 

Trazodone and alcohol interaction

It is advised to preferably avoid or limit alcohol consumption while being treated with Trazodone.

Alcohol intake while using Trazodone can increase the side effects and in addition, some people may also experience impairment in thinking and judgment. 

Trazodone Side effects (A complete guide)

Is it safe to take trazodone for insomnia?

Trazodone is widely prescribed as a nighttime sleep aid for people with acute insomnia, even though it was originally designed to treat depression and anxiety disorders. 

Is trazodone different from other “sleeping pill” drugs?

The most commonly prescribed drugs as sleeping aids are Ambien, Sonata or Lunesta, but Trazodone differs from them in a few ways such as:

  • Ambien and Lunesta have the potential for misuse and abuse (dependence or addiction) so they are classified as controlled substances.
  • Trazodone is not considered to be an addictive substance, hence it is not a controlled substance so physicians aren’t limited in how many pills they can prescribe
  • Compared to other drugs it is an inexpensive generic drug covered by most insurance companies
  • Trazodone is not recommended to be taken by pregnant women or women who are breastfeeding. 

Are there risks while taking trazodone as an antidepressant?

For someone under the age of 24, there are heightened risks in regards to mental health.

According to MedlinePlus, the following side effects and symptoms can occur among patients under age 24: “new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement.” 

It is important to be aware that the manifestations of any of these symptoms or side effects should be discussed with your doctor immediately. 

When treated with Trazodone, it is important to be aware of avoiding taking other medicines classed as SSRIs, SNRIs or other antidepressants.

Additionally, if you have a cold, an allergy or you are having trouble sleeping, before you take over-the-counter medication to treat the symptoms consult with your doctor.

Trazodone Side effects (A complete guide)

Is it safe to use trazodone with alcohol or other drugs?

It is recommended to avoid or limit the consumption of alcohol while using Trazodone since both substances affect the central nervous system, and the consequences have been described as fatal.

Additionally, missing this medicine with drugs of abuse can cause serotonin syndrome, potentially fatal as well.

While trazodone is not considered addictive, any amount over 600 mg in 24 hours is an overdose.

Can you become addicted to trazodone?

Trazodone is a non-controlled substance and it is considered non-addictive and non-habit-forming, however, it should only be taken as prescribed and under a physician’s care in order to avoid misuse, especially if you have a history of substance abuse or other drug addiction.

Some of the warning signs of drug misuse can be using the medication without a prescription, using it at higher doses than recommended/prescribed or snorting or crushing the tablets to speed up the intended effects.

Why is this blog about Trazodone side effects important?

If you are considering taking this drug for depression, sleeping disorders or anxiety, it is important to be aware of trazodone  side effects and warning signs of a major medical complication that can be manifested. 

Additionally, it is important to follow the instructions provided by your doctor on how to take the medication correctly and inform immediately if there are complications.

Although we consider this guide for Trazodone side effects compiled accurate and up to date information from trustworthy medical sources, it is not intended as a strict how-to guide, it is only informative.

Additional questions or concerns about Trazodone side effects should be answered by your doctor.

Please feel free to comment on the content of this guide in the comments section below. 

Side Note: I have tried and tested various products and services to help with my anxiety and depression. See my top recommendations here, as well as a full list of all products and services our team has tested for various mental health conditions and general wellness.

Frequently Asked Questions (FQAs) about Trazodone Side effects

Is Trazodone a sleeping pill?

Trazodone is often used as a sleeping pill since one of its side effects is drowsiness, so it is said to help people fall asleep.

How long does it take for Trazodone to kick in for sleep?

Some people who use this drug for sleep disorders have indicated that they get to experience the sedative effect within 30 mins after the intake, but remember that every person can react differently to the drug.

What are the long term side effects of trazodone?

Some of the long term side effects of trazodone include: blurred vision, headaches, vomiting, drowsiness, confusion, hypotension, insomnia, among others. 

Do trazodone side effects go away?

Trazodone side effects for some people can go away as the treatment progresses.

However, this is not a general rule for everyone that takes Trazodone since everybody can react differently to the treatment.

If the side effects persist, get in touch with your doctor to discuss other possible treatments for you.

How many hours does trazodone last?

After a single dose taken by a healthy adult, it will be mostly out of your system in 1 to 3 days.

The half-life for trazodone is approximately 5 to 13 hours. 

Recommended reading

  1. Trazodone Hydrochloride; Third Edition
  2. Trazodone 627 Questions to Ask that Matter to You 
  3. Trazodone: Webster’s Timeline History, 1973 – 2007
  4. Trazodone: New Clinical Applications and Safety Considerations for a Third Generation Antidepressant 4th World Congress of Biological Psychiatry, … Antidepressant – Symposium Proceedings
  5. Trazodone – A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

What we recommend for depression

Professional counselling

If you are suffering from depression then ongoing professional counselling may be your ideal first point of call. Counselling will utilize theories such as Cognitive behavioural therapy which will help you live a more fulfilling life.

References

Drugs.com

Cigna

Hazelden Betty Ford Foundation

MedPlus

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