Is the combination of Lexapro and Wellbutrin effective? (3+ reviews) 

In this blog post, we are going to answer the question, “Is the combination of Lexapro and Wellbutrin effective?”. Lexapro and Wellbutrin are both antidepressants which belong to two different classes. 

Although they both have different mechanisms of action, they both can be used in the management and treatment of mild to severe episodes of depression, anxiety, and several other mental health conditions. This blog will cover the success rate of this combination and what actual people have to say about it. 

Is the combination of Lexapro and Wellbutrin effective?

Yes, the combination of Lexapro and Wellbutrin is quite effective. Both of these meds are good at what they do and this combination at low doses can significantly help recover people from their mental health conditions. 

Several research studies have indicated that this combination has been tolerated well by people for decades now, and it works very well in the management and treatment of symptoms associated with major depressive disorder (MDD), a kind of depression that does not respond to monotherapy of antidepressants. 

Lexapro, brand name for Escitalopram, is a selective serotonin reuptake inhibitor (SSRI). It works by inhibiting the reuptake of serotonin by blocking serotonin transporters (SERT). 

This way, more serotonin is available to bind to its respective receptors and counteract the symptoms associated with depression. Wellbutrin, brand name for Bupropion, belongs to another class of antidepressants called Dopamine-norepinephrine reuptake inhibitors (DNRI). 

This med works by inhibiting the reuptake of two excitatory neurotransmitters; dopamine and norepinephrine. This way, more amount is available to bind to the respective receptors and make you feel better, calm, and relaxed. 

What actual people have experienced so far? 

Many people have come forward and revealed what they have experienced while being treated with the combination of Lexapro and Wellbutrin. One user stated:

“I was diagnosed with depression when I was pretty young. My doctor prescribed Zoloft at first, but I could not tolerate the effects of this antidepressant. That’s when my doctor shifted me to Lexapro. It did help me, but not completely.”

The user further stated:

“I knew I had depression, but I did not know I had major depressive disorder. When my doctor figured out that I’m not responding that well to the treatment of Lexapro alone, that’s when my doctor told me that I had MDD and monotherapy of only Lexapro will not help me recover.”

The user continued:

“The biggest symptom of my MDD was lethargy. At some point, I started to think that I have some kind of a chronic fatigue disorder, but that was my MDD killing me. That’s when my doctor paired Lexapro with Wellbutrin. That was the best thing that happened to me. I slowly started to recover and the combination worked really well for me.”

It is indeed a good review. Major depressive disorder (MDD) is the most stubborn and persistent kind of depression that does not respond to normal treatment. It is often misdiagnosed as moderate depression, but as the disease progresses, the signs start to become more obvious. 

This is why the proper diagnosis of MDD is crucial for the safe and effective treatment and management of this nerve-racking illness. Once MDD is diagnosed, it is not treated by monotherapy of antidepressants. It usually requires the combination of such meds. Another user of the combination of Lexapro and Wellbutrin stated:

“Depression is the worst kind of illness one can suffer from. It is much more difficult to manage than you could think. I always had poor mental health, but I never figured out that it was clinical depression. I was never fond of meds so I never even considered going to a doctor thinking that stress and depression is usually a phase of life and it will go away on its own.”

The user continued:

“While I kept trying to be optimistic, my mental health kept deteriorating. That’s when my family persuaded me to visit a mental healthcare professional and that’s what I did. When I told everything that had been bothering me, my doctor told me right at that moment that I have all the clinical signs and symptoms related to MDD.”

The user further stated:

“My doctor prescribed me the combination of Lexapro and Wellbutrin right away. The two meds worked amazingly well for me and I always tried to take them as properly as I could. It’s been 7 months now and I’m at my better, and much happier version.”

This review indicated how much of a trouble MDD is. No matter what you do, you can distract yourself physically or mentally when you suffer from MDD. It’s clinical depression and it needs a combination of good antidepressants to go away. 

I’m glad our user here got good results in seven months. Several surveys revealed that some people can take upto a year or even more than that to recover. Another user stated:

“I have been on antidepressants for quite a while now but nothing has worked for me as perfectly as the combination of Lexapro and Wellbutrin. The two antidepressants helped me recover from the toughest of times that my depression gave me. I was so torn within myself that I wanted to end this misery.”

The user further stated: 

“I tried a number of times to take my own life. Yes, it may sound disturbing but that was once my reality. I have tried a bunch of antidepressants and switched many times. When Lexapro and Wellbutrin started working in my system, I could feel that the voices in my head started to fade away. I felt calmer and more relaxed. Soon the suicidal thoughts were long gone.”

This is such a wholesome review. One of the terrible symptoms associated with major depressive disorder (MDD) is suicidal behaviour. It’s completely inevitable. Some surveys learned about stuff that happened to people who actually ended their lives. 

Their friends and family revealed that some of them met the deceased just a few hours before they took their lives. They seemed sad, but not sad enough to do something like this. 

Some of them ate food, laughed a little, and seemed okay when they were last seen, but a few hours later they ended their lives. It indicates how inevitable suicide attempts are with MDD. 

You can never figure out what a person is feeling from the inside because you only see what they let you see. This is why you should always consult a mental healthcare professional when you begin to notice behavioural changes in yourself or someone close to you. 

What are the side effects associated with the use of Lexapro and Wellbutrin? 

Both Lexapro and Wellbutrin are associated with some side effects. Let’s look at them individually. 

Side effects of Lexapro 

Some of the common side effects associated with the use of Lexapro include

• Nausea 
• Vomiting 
• Diarrhoea or Constipation 
• Acid reflux or heartburn 
• Abdominal pain 
• Loss of appetite 
• Weight gain or loss 
• Excessive sweating or night sweating (nocturnal/night hyperhidrosis) 
• Frequent urination 
• Polydipsia or excessive thirst
• Tremors 
• Muscle twitching and pain
• Drowsiness 
• Dizziness 
• Excessive tiredness or fatigue 
• Insomnia or inability to fall asleep 
• Xerostomia or dry mouth 
• Dysmenorrhea or heavy periods
• Flu-like symptoms, including irritation in the eyes and a runny nose
• Loss of libido in both males and females. Males may suffer from an inability to release, while females may suffer from an inability to have a climactic experience. 

Side effects of Wellbutrin 

Some of the side effects associated with the use of Wellbutrin include:

• Anxiousness 
• Unexplainable excitement and happiness 
• Insomnia or inability to fall asleep 
• Xerostomia or dry mouth 
• Dizziness 
• Drowsiness 
• Nausea with or without vomiting 
• Abdominal pain 
• Headache 
• Tremors 
• Weight loss 
• Loss of appetite 
• Tinnitus or ringing in the ears 
• Excessive sweating 
• Altered sense of taste and smell
• Constipation 
• Throat infection 
• Increased frequency of urination

Make sure you take these two meds properly. This is the only way to achieve a safe and effective therapeutic response. Make sure you do not take any more than the prescribed dose. Higher doses can cause terrible side effects and can result in life-threatening complications. 

Conclusion 

In this blog post, we have discussed the concomitant use of Lexapro and Wellbutrin. We have also looked at some reviews from actual people and learned how the combination of Lexapro and Wellbutrin actually works. 

Both of these meds are good at what they do and this combination at low doses can significantly help recover people from their mental health conditions. Make sure you take these two meds properly. This is the only way to achieve a safe and effective therapeutic response.

FAQs: Lexapro and Wellbutrin combo reviews 

Are Lexapro and Wellbutrin a good combination?

Yes, Lexapro and Wellbutrin is considered a good combination. Both of these meds are good at what they do and this combination at low doses can significantly help recover people from their mental health conditions. Make sure you take these two meds properly. This is the only way to achieve a safe and effective therapeutic response. Make sure you do not take any more than the prescribed dose. Higher doses can cause terrible side effects and can result in life-threatening complications.

Why do doctors prescribe Wellbutrin and Lexapro together?

Several research studies have indicated that the combination of Lexapro and Wellbutrin has been tolerated well by people for decades now, and it works very well in the management and treatment of symptoms associated with major depressive disorder (MDD), a kind of depression that does not respond to monotherapy of antidepressants. 

Can you take Lexapro and buPROPion together?

Yes, you can take Lexapro and Wellbutrin, but only if prescribed by your healthcare provider. The combination can be used in the treatment and management of major depressive disorder (MDD), which is a treatment-resistant kind of depression. Make sure you do not take any more than the prescribed dose. Higher doses can cause terrible side effects and can result in life-threatening complications.

Can you combine Wellbutrin with other antidepressants?

Yes, you can combine Wellbutrin with other antidepressants. Selective serotonin reuptake inhibitors are probably the best choice of antidepressants to be combined with Wellbutrin. There are a huge number of research studies that can claim the therapeutic efficacy and safety of this combination. 

However, not all SSRIs can produce fruitful results. SNRIs are also considered good when it comes to the combination treatment with Wellbutrin. Studies suggest that several case studies showed good responses to the combination treatment of Wellbutrin and SNRIs. 

References 

• An Open Pilot Study of the Combination of Escitalopram and Bupropion-SR for Outpatients With Major Depressive Disorder https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778329/ 
• Sidney Zisook et al. Biol Psychiatry. (2006) – Use of bupropion in combination with serotonin reuptake inhibitors https://pubmed.ncbi.nlm.nih.gov/16165100/
• Chu A, Wadhwa R. (2015) – Selective serotonin reuptake inhibitors https://www.ncbi.nlm.nih.gov/books/NBK554406/#_NBK554406_pubdet_