How long does it take for the increased dose of Wellbutrin to work?

This article will discuss how long after your dose of Wellbutrin is increased it will start to work. For that, the article will explain what Wellbutrin is, how it works in the person’s body, and what are its side effects.

How long does it take for the increased dose of Wellbutrin to work? 

If you are taking Wellbutrin and your dosage is increased, you may feel the first benefits of it between the first and the second week. You may start to feel an increase in your energy level, along with your sleep, appetite, and libido. 

But to feel an improvement in your overall symptoms of depression, it can take around 6 to 8 weeks.

Taking Wellbutrin is completely safe, there are no signs of problems with taking it for a prolonged period. The medication can be taken in 3 different forms: immediate-release (IR), sustained-release (SR), or extended-release (ER). 

If you are taking the immediate-release form, it can be taken from 2 to 3 times a day and it usually works right after you take it. You should wait between 4 and 6 hours from one dose to the next. It can go from 100 mg if taken twice a day to 150 mg if taken 3 times. But you should only take the last dose until mid-afternoon.

The sustained-release form can be taken twice a day, usually in the morning and in the afternoon. And the dosage goes from 100mg to 200mg. As for the extended-release, it is taken once a day, and it goes from 150mg to 450mg.

The form you will take and the dosage will be defined by your doctor according to your condition, and other factors surrounding your health. So you should always stick to what dosage your doctor has prescribed you. If you take over what he prescribed you may increase your chances of having a seizure. 

If you miss a dose, and you take the IR or SR form, take it as soon as you can, but only if you can keep each dose apart from the other for more than 4 hours. But don’t take two tablets at once. If there are less than 4 hours for your next tablet, just leave it for the next dose.

Don’t stop taking Wellbutrin by yourself. If you want to stop it, talk to your doctor. A sudden stop to it can cause you to experience signs of withdrawal. 

What is Wellbutrin?

Wellbutrin, also known as Bupropion, is an antidepressant. They are used to treat the major depressive disorder and seasonal affective disorder. 

Along with that, even though it doesn’t say on the label, it can be used to treat Attention-deficit/hyperactivity disorder (ADHD), as well as bipolar disorder, anxiety, and obesity. It is a part of a class of antidepressants called norepinephrine-dopamine reuptake inhibitors (NDRIs). 

How does Wellbutrin work? 

Since it is an antidepressant of the NDRIs type, it aims to increase the levels of the neurotransmitters dopamine and norepinephrine. Through that, you can improve the person’s mood and overall sense of well-being.

How long does it take for the increased dose of Wellbutrin to work?

What are the side effects of Wellbutrin? 

Wellbutrin can cause side effects. They are usually mild ones that can go away after a few weeks after your body has grown accustomed to them. The most common side effects of Wellbutrin are Abdominal pain, anxiety, a decrease in appetite, and a change in how food tastes. 

Along with that, it can lead to constipation, dizziness, dry mouth, flushing, hair loss, headache, sweating, and trouble sleeping.  Wellbutrin can also cause nausea, inability to relax, tremors, ringing in the ear, vomiting, weakness, and weight loss.

But some people can experience some more severe side effects. They can have an allergic reaction to the medication, become aggressive, agitated, and go through changes in their menstrual cycle, or in their sexual desire.

It can also cause chest pain, dark urine, confusion, delusion, and difficulty breathing. Not only that, it can lead to euphoria, fainting, fever, and impulsive and hostile behavior. Wellbutrin can cause panic attacks, fast heartbeat, seizures, difficulty concentrating, yellow skin and eyes, and swelling.

If you feel like you are experiencing its common side effects through a prolonged period, or that you are going through severe side effects, you may want to get in touch with your doctor. In talking to them you can adjust the dosage, or even consider changing the medication.

What should be taken under consideration when taking Wellbutrin?

Although Wellbutrin is a perfectly safe drug, some things need to be taken into consideration. It shouldn’t be taken if you have an eating disorder, glaucoma, or seizures. 

Along with that, when it is prescribed to people with bipolar disorder the doctor needs to keep a closer look. That is because it can increase the risk of people developing manic, mixed, or hypomanic episodes, as well as suicidal thoughts. 

Let your doctor know if you have a kidney or liver problem, since with those you may need to take a lower dosage of Wellbutrin. And never take it if you have any sign of allergies to it. 

When discussing its safety, Wellbutrin has not been proven to be completely safe for children and pregnant women. Although if the pregnant woman or the woman that is breastfeeding is in a serious emotional condition, the benefits of it may overlap the possible risks. The only necessity is for the doctor to keep a closer look at the patient in those situations.

Along with that, if you and your doctor are discussing that you should take Wellbutrin you may want to let them know about all the medications you have been taking. Through that, he can analyze the possible interactions between them. 

Wellbutrin may affect or be affected by the use of blood thinners, corticoids, other antidepressants, MAOIs, and some antipsychotics.

Frequently Asked Questions (FAQ): How long does it take for the increased dose of Wellbutrin to work? 

What are the most common antidepressants? 

Antidepressants are the type of medication people take when they are going through a depressive episode. The most commonly prescribed antidepressant is the Selective serotonin reuptake inhibitors (SSRIs) because they usually have fewer side effects, two examples of it are Fluoxetine and Citalopram.

Another form of antidepressant that commonly can be prescribed is the Serotonin-noradrenaline reuptake inhibitors (SNRIs). This type is similar to SSRIs but was created to be more effective than SSRIs. An example of SNRIs is venlafaxine.

Does everyone react the same way to mental health medication? 

No, people can react differently to mental health medication. The side effects can change from one person to the other, and how each person may feel it working can also change. That is why it is important to be followed by a mental health professional. 

They will help you understand if the benefits you should be experiencing from the medication should be higher, so they need to change your dosage or even change your medication. The same is said about the side effects. If you start having too many of them, maybe your doctor will consider changing the medication.

Is only medication enough to treat mental illness?

No, to treat mental illness a person may need a joint treatment between medication, therapy, and maybe even the help of other professionals. The medication will work mostly on reducing your symptoms, and try to revert the chemical imbalance that is happening in your brain.

To understand your emotions better, and become aware of your patterns and triggers, you may need to go through therapy. It is only with that, that once you stop taking the medication, you will be able to react differently when you face your triggers.

Do only psychiatrists prescribe mental health medication?

No, they are not the only ones that can prescribe it. But one should always try to go to a psychiatrist when going through mental illness. This will guarantee that you are being treated by someone that specializes in the condition you are going through and knows how to care for it properly.

Even though other doctors, such as general practitioners may be able to prescribe you these medications, then follow-up with them may not be as specialized as it would be with a psychiatrist.

If you haven’t found the one you feel comfortable with, you may want to look for referrals from people you know. It can be a process to find someone you feel comfortable talking to, but that makes a lot of difference in the quality of your treatment.

Will I experience side effects with all mental health medications?

It is not possible to say if and which side effects you can go through when taking mental health medication. That is why there is such a large list of possible side effects on each medication.

Two people taking the same dosage of the same medication can feel completely different. One may have such intense side effects that they may need to change medication, as for others, they can even experience no side effects at all.

The importance of knowing what side effects your medication can give is that you follow how you feel, and if the side effects become too intense, or lasts too long, you can get in touch with your doctor to adjust it.

Can I change my medication by myself?

You should never change your medication by yourself. You must understand your treatment. And you should be cared for by a doctor that is willing to clear all your doubts and explain to you what is expected of each step of your treatment.

So reading about it, and looking for new information is valuable. But never decide to change your course of treatment without discussing it with your doctor. If you have discovered a new medication, and it seems to you it would fit your condition, you can make an appointment with your doctor.

In that, take all the material you have gathered, and show them why you think it may be a good idea to change medication. It is extremely important to hear what they have to say. 

And if they agree it may be a good thing to try changing your medication, follow their instructions in stopping the one you have been taking, and starting the new one.

Keep in mind that there is a process to be made in those cases so you don’t experience intense side effects or even withdrawal from the medication you are stopping.


This article discussed how long after your dosage of Wellbutrin is increased you will feel the improvement. For that, the article explained what Wellbutrin is, how it works, and what are its side effects. 

If you have any questions or comments about this article, feel free to write them in the section below.


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