How long does 7.5 mg mirtazapine stay in your system?

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In this blog post, we are going to answer the question, “How long does 7.5 mg mirtazapine stay in your system?”. Mirtazapine is an antidepressant which is used to treat a number of mental health related problems. 

This blog will cover the stay time of mirtazapine in your system and we will also learn about the clinical importance of 7.5mg mirtazapine. 

How long does 7.5 mg mirtazapine stay in your system? 

7.5mg mirtazapine stays in your system for about 4 to 8 days. The half life of 7.5 mg mirtazapine is 20-40 hours. This indicates that the concentration of this antidepressant reduces to half after this time period, that is, it tones down to 3.75mg. 

This 3.75mg further reduces to half (1.875 mg) after the next 20-40 hours. This is how the concentration of mirtazapine keeps getting lower and lower until it is finally removed from your system. 

So, 7.5mg of mirtazapine is removed from your body in about 6-8 days, if we include the traces as well. However, this time duration can vary from person to person. 

Some people have some underlying diseases that may affect the entire process of drug metabolism. Usually, in order for a med to be metabolised, it has to go through some steps. 

When you ingest the tablet, it goes into your stomach and goes through the process of dissolution where the drug is dissolved. It is then absorbed into the systemic circulation (blood) which takes it to the respective active site. 

This blood also carries the drug to the liver, a detoxifying organ in our body. Liver has an entire enzyme system which is responsible for breaking down the drug into its metabolites. These metabolites are then eliminated from the body. 

Now, you can imagine how many processes take place just for a single tablet to be excreted out of your body. Several people have conditions that can affect one or more of these pathways. 

If the absorption of the drug is hindered in some individuals, it will obviously take longer for such people to get the drug out of their system. Some people have compromised liver and kidney functions which makes this process even longer. 

This indicates that the time taken by mirtazapine to be completely removed from your body depends on your physiology or any underlying disease you might have. 

What is the clinical significance of 7.5mg mirtazapine? 

Mirtazapine (Brand name: Remeron) is an antidepressant. It does not belong to any typical class of antidepressants and its mechanism of action is different from SSRIs and SNRIs. It does not block the reuptake of serotonin by any pathway. 

Mirtazapine (Remeron) belongs to the tetracyclic antidepressants. It has a dual mode of action. Mirtazapine is believed to be responsible for the activation of 5-HT1 receptors, which are one of the serotonin receptors. This antidepressant also acts on the noradrenergic system. 

Experts believe that remeron enhances the stimulatory action of the noradrenergic system which increases the secretion of serotonin. It also prevents the inhibitory action of the noradrenergic system which hinders the release of serotonin. 

This way, it actively increases the amount of this excitatory neurotransmitter in your system. This medication is used for the treatment of following health conditions:

Depression 

Mirtazapine is used in the treatment of mild to major depression disorder (MDD). It is a state of mind which is concerned with disturbing thoughts, especially about one’s self. 

It is associated with symptoms like hopelessness, tearfulness and emptiness. Depression is caused by the deficiency of excitatory neurotransmitters. 

Mirtazapine increases the amount of active serotonin to help relieve the symptoms of depression. Serotonin is an excitatory neurotransmitter responsible for modulating mood, cognition, reward, learning, memory, and various other psychological processes. 

Anxiety 

Mirtazapine is also used to treat generalised anxiety disorder. As the name implies, this mental health condition is associated with general worry or anxiety about pretty much everything without having any logical reason. 

People suffering from GAD worry about small matters related to family, friends, relationships, study, work, health, wealth etc. 

Treatment resistant depression 

Treatment resistant depression is the kind of depression that does not go away after typical antidepressant treatment. Experts believe that mirtazapine is a good option to treat depression that has been resistant to normal SSRI or SNRI treatment. 

Depression in elderly patients

Mirtazapine has been a good antidepressant to treat depression and the disturbing symptoms associated with it in geriatric population. The drug seems to control mood problems quite well in such patients. 

Post-operative nausea

Mirtazapine can also be used to help control nausea that usually becomes a problem after operative procedures. 

Alcohol dependence

Mirtazapine can also be used to control alcohol dependence or alcoholism. Its mode of action in this case is still a topic of research and so is its safety and efficacy. However, it is not recommended to take mirtazapine with alcohol as the two don’t pair that well together. 

Insomnia or inability to fall asleep 

Mirtazapine can significantly help improve your sleep cycle by providing relief in the disturbances that might occur when you try to fall asleep. It also increases the duration of your sleep and reduces the frequency of nighttime wakefulness, especially in people who have insomnia comorbid with depression. 

Neuropathic pain

Mirtazapine can also be used for neuropathic pain. The med can significantly reduce the intensity of this throbbing kind of pain and increase the frequency of pain-free episodes. 

Inability to feel hungry/hunger suppression

Mirtazapine can be used to boost appetite in people who are not always hungry. Several studies revealed that mirtazapine can significantly help people with anorexia nervosa. However, when the drug is solely used for the treatment of depression, it may make you gain weight as a side effect. 

What are the recommended doses of mirtazapine? 

Mirtazapine is recommended in the following doses:

Depression 

  • For adults: The treatment is usually started from 15 mg/day, taken usually at morning or whatever time is suggested by your healthcare provider. However, the dose can be adjusted by the healthcare provider if needed and should not exceed 45 mg/day. 
  • For children: Dose is suggested by the doctor according to the condition and body weight.

Other health conditions

  • For adults: The treatment is usually started from 15 mg/day, taken usually at morning or whatever time is suggested by your healthcare provider. However, the dose can be adjusted by the healthcare provider if needed and should not exceed 45 mg/day. 
  • For children: Dose is suggested by the doctor according to the condition and body weight.

Make sure you take your medication properly and take just as much as your healthcare provider has recommended. It is not suitable for you to take more or less than that. In case of overdose, immediately reach out to the hospital. 

Make sure you properly guide them about how much drug you have taken and when. If you have missed a dose and you’re way past the usual time at which you take your med, do not take it. It will cause you to overdose when you take your next dose, which is not too far away. 

It’s better to skip the missed dose and take the next one. If you remember your missed dose earlier, it’s safe for you to take it. Antidepressants are not that simple when it comes to missing a dose. 

It’s a common practice among people who have busy schedules to forget to take their meds. But antidepressants, including mirtazapine, are a bit typical in case of missing a dose. 

Most people can experience symptoms similar to those of discontinuation syndrome, especially those who are at higher doses. Symptoms are much more intense in people using antidepressants with shorter half-lives.

Conclusion 

In this blog post, we discussed the time taken by 7.5mg mirtazapine to get out of your system. We have found that 7.5mg mirtazapine stays in your system for about 4 to 8 days. The half life of 7.5 mg mirtazapine is 20-40 hours. 

The concentration of this antidepressant keeps dropping to half until it completely washes out of your system. This time period can not be the same for everyone because it depends on a lot of factors. People who have disturbed metabolic functions can have mirtazapine in their system for a longer period of time. 

Make sure you use this medication or any other medication only when your doctor has advised it. Using medications which can affect your brain is not something ideal and should not be encouraged unless it is absolutely necessary to do so. 

FAQs: how long does 7.5 mg mirtazapine stay in your system

How do I wean off 7.5 mg of mirtazapine?

The best way to wean off 7.5 mg mirtazapine is to slowly taper the dose and keep reducing it until you reach the lowest possible dose. Your doctor would want you to stay on the lowest dose as long as your body takes to adjust to it and then the drug is finally stopped. You may suffer some of the withdrawal symptoms even after tapering this antidepressant off properly, but it would be easier to manage these symptoms. 

How long does it take mirtazapine to get out of your system?

Mirtazapine stays in your system for around 4-8 days. This antidepressant has a half life of about 20-40 hours. It means that the concentration of the drug is reduced to half after this time period. The remaining amount is further reduced to half in the next 20-40 hours. 

This process keeps on ongoing until the drug is completely washed out from your body and it can take upto 4-8 days for the process to happen. However, this time duration can vary from person to person. Some people have some underlying diseases that may affect the entire process of drug metabolism

Is 7.5 mg mirtazapine effective?

Yes, 7.5 mg mirtazapine is quite effective. Although it is a low dose, it does hold clinical significance. Experts believe that mirtazapine enhances the stimulatory action of the noradrenergic system which increases the secretion of serotonin. It also prevents the inhibitory action of the noradrenergic system which hinders the release of serotonin. 

This way, it actively increases the amount of this excitatory neurotransmitter in your system. Mirtazapine can be used to treat the following health conditions:

  • Depression 
  • Anxiety 
  • Treatment resistant depression 
  • Depression in elderly patients
  • Post-operative nausea
  • Alcohol dependence
  • Insomnia or inability to fall asleep 
  • Neuropathic pain
  • Inability to feel hungry/hunger suppression

What happens if you stop taking mirtazapine?

Abrupt withdrawal of mirtazapine leads to withdrawal or discontinuation syndrome. When you start taking antidepressant, it increases the amount of serotonin in your body. which your body reacts in a negative way. You may suffer from the following symptoms:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Nightmares
  • Excessive dizziness
  • Confusion
  • Delirium
  • Emotional stress
  • Impaired motor coordination
  • Intrusive thoughts

How long does it take to feel normal after stopping mirtazapine?

The time taken by your body to completely adjust without mirtazapine depends on your physiology. There is no standard time duration for this and it hugely varies from person to person. Some people start to get better in just a few weeks, while others may take 6 to 7 months to feel completely normal again. 

References 

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