Efficacy of wellbutrin and prozac together

In this article, we will discuss, if you should take prozac and wellbutrin together, what may be the risks of doing so, is it advisable to take this combination, common side effects of the drugs and which drugs interact with wellbutrin and prozac. 

What happens when you take wellbutrin and prozac together?

Do not self medicate, always ask your doctor before taking any kind of medications. 

Combining these medications may increase the chance of seizures, which can happen with either of them in rare cases. Furthermore, bupropion can raise Fluoxetine levels in the blood, thereby increasing additional negative effects.

Prozac and wellbutrin both target serotonin and norepinephrine, two important neurotransmitters linked to the treatment of depression.

Each one may work on its own, but a combination of the two may be more effective in alleviating symptoms, in some cases not all. 

If you’re elderly, going through alcohol or drug withdrawal, have a history of seizures, or have a disorder affecting the central nervous system like a brain tumour or head trauma, you’re more likely to have seizures while taking these medications.

 To safely use both medications, your doctor may be able to prescribe alternatives that do not interfere, or you may need a dose change or more frequent monitoring by your doctor.

During treatment, you should avoid or limit your alcohol consumption. All other prescriptions, including vitamins and herbs, should be disclosed to your doctor. Stopping any drugs without first consulting your doctor is not a good idea.

Is it effective to take this combination of medication? 

Taking this combination of medication may prove helpful to some people, but not everyone. This combination is also known to cause some serious side effects too. Therefore, you should consult your doctor before making this decision.  

Wellbutrin (Bupropion) is an effective treatment for MDD on its own, but it can also be used with other drugs to treat difficult-to-treat depression.

In fact, Wellbutrin (bupropion) is one of the most widely prescribed drugs in combination therapy. It’s frequently combined with antidepressants like selective serotonin reuptake inhibitors (SSRIs lIke Prozac) and serotonin-norepinephrine reuptake inhibitors (SNRIs).

Although not an approved use, the combination of bupropion and either an SSRI or an SNRI appears to be well tolerated, can boost antidepressant response, and can lessen SSRI or SNRI-associated sexual adverse effects, according to the existing data. Additional controlled trials are needed to answer critical problems, such as the best dose and treatment duration.

However, the advantages of taking this combination of medications may exceed the dangers of therapeutic duplication. This information is not a substitute for speaking with your doctor. Always check with your healthcare practitioner to see if any medication changes are necessary.

What is therapeutic duplication?

The use of more than one medicine from the same medicinal category or therapeutic class to treat the same disorder is known as therapeutic duplication

When medications with comparable effects are administered together for proven benefit, this can be done on purpose. It can also happen unintentionally when a patient is treated by multiple doctors or has prescriptions filled at multiple pharmacies, and it can have serious effects.

Are Prozac and wellbutrin the same thing?

They both are antidepressants. However, Wellbutrin and Prozac are different types of antidepressants.

Prozac is a selective serotonin reuptake inhibitor (SSRI) and Wellbutrin is an aminoketone.

Read more about SSRIs here 

Both of these medications are used to treat Major depression. 

Bulimia, obsessive-compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder are all treated with Prozac .

Read more about Wellbutrin here

Dry mouth, sleeplessness, headache, nausea, constipation, stomach upset or pain, dizziness, decreased sex desire, sore throat, changes in appetite, or weight fluctuations are all common side effects of Wellbutrin and Prozac.

Common side effects of Wellbutrin and prozac

Dry mouth, sleeplessness, headache, nausea, constipation, stomach upset or pain, dizziness, decreased sex desire, sore throat, changes in appetite, or weight fluctuations are all common side effects of Wellbutrin and Prozac.

Agitation, vomiting, ringing in the ears, visual issues or blurred vision, muscular discomfort, itching or skin rash, increased sweating, increased urination, tremor, joint aches, peculiar taste in the mouth, diarrhoea, and seizures are all side effects of Wellbutrin (especially at higher doses)

Anxiety, drowsiness, nervousness, heart palpitations, cold symptoms (stuffy nose, sneezing), impotence, or difficulties having an orgasm are all side effects of Prozac that are distinct from Wellbutrin.

Prozac is an SSRI that raises serotonin levels in the brain and is used as a first-line treatment for depression. Any weight reduction you may have while taking Prozac could be transitory, and you could recover weight after a few months.

Wellbutrin and Prozac, like all antidepressants, come with a black box warning. During the early phases of treatment, they have a higher risk of suicide thoughts and behaviours in adolescents, teens, and young adults.

What drugs interact with Wellbutrin?

Insulin, blood thinners, and asthma medicines may interact with Wellbutrin. Many medications, including heart or blood pressure medications, HIV or AIDS treatments, seizure medications, other antidepressants, psychiatric medications, antibiotics, and sleep-inducing antihistamines, may interact with Wellbutrin.

Bronchodilators, birth control pills or hormonal therapy, bladder or urinary medications, diet pills, stimulants, ADHD medications, oral diabetes medications, nausea/vomiting/motion sickness medications, malaria medications, Parkinson’s disease medications, restless leg syndrome medications, pituitary gland tumour medications, medicines used to prevent cancer are some other drugs that interact with Wellbutrin. 

What drugs interact with Prozac?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, seizure or anxiety medicine, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs , other antidepressants, blood thinners, or migraine headache medicines may all interact with Prozac.

Alprazolam, clopidogrel, clozapine, flecainide, haloperidol, nebivolol, vinblastine, and seizure medicines may all interact with Prozac.

If you stop taking Prozac suddenly, you may have withdrawal symptoms.

Conclusion

In this article, we discussed the possible effects of taking wellbutrin and prozac together, if it is advisable to take these medications together, common side effects of both and which drugs interact with wellbutrin and prozac. 

FAQs

How does Wellbutrin and Prozac work together?

Antidepressant drugs Wellbutrin and Prozac both function in different ways. Wellbutrin is an aminoketone that acts by boosting norepinephrine and dopamine levels in the brain. Prozac is an antidepressant that works by raising serotonin levels in the brain.

Why do people take Prozac and Wellbutrin?

Antidepressants such as Wellbutrin (bupropion) and Prozac (fluoxetine) are used to treat major depression. Seasonal affective disorder is also treated with wellbutrin. Bulimia, obsessive-compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder are all treated with Prozac.

What is the best combination of antidepressants?

Sertraline and escitalopram are the most effective.

The researchers looked at numerous second-generation antidepressants using fluoxetine as a reference medicine. The best combination of efficacy and acceptability was found in sertraline and escitalopram.

What gives more energy Prozac or Wellbutrin?

Wellbutrin (Bupropion) helps you relax and improves your mood. Prozac (fluoxetine) is an antidepressant and anxiety medication. Because it is more stimulating than other antidepressants, it may not be the ideal option for persons who have difficulty sleeping.

Can you take another antidepressant with Wellbutrin?

Although not an approved use, the combination of bupropion and either an SSRI or an SNRI appears to be well tolerated, can boost antidepressant response, and can lessen SSRI or SNRI-associated sexual adverse effects, according to the existing data.

References

https://www.drugs.com/drug-interactions/prozac-with-wellbutrin-1115-648-440-203.html
https://pubmed.ncbi.nlm.nih.gov/16165100/
https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2009.09121768

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