Does green tea interact with Zoloft? (3 side effects) 

In this article, we will discuss whether green tea interacts with Zoloft. We will also talk about some research studies and potential side effects of this combination. We will also discuss whether you can occasionally enjoy green tea while taking Zoloft.

Does green tea interact with Zoloft?

Zoloft can interact with green tea, and this combination can cause some additive side effects. Green tea can affect the metabolism of Zoloft (sertraline), a selective serotonin reuptake inhibitor (SSRI) primarily used as an antidepressant (1,2). 

However, the amount of green tea consumed and how well you tolerate Zoloft can make a difference. It’s a known fact that people are different and have different factors affecting their health. 

If you’re sensitive to the effects of Zoloft or consume green tea excessively while being treated with this antidepressant, you can experience side effects, which may vary in intensity from person to person. 

If you’re experiencing unusual symptoms while taking the two together, please reach out to your doctor. It is generally advisable to limit your tea, coffee, and alcohol intake while taking antidepressants to ensure the safety and efficacy of your treatment.

What does research suggest?

Research studies have not established a direct link between green tea and Zoloft, but data does show us that these two can potentially interact. One research study indicates that consuming green tea with antidepressants can affect their absorption (3). 

Furthermore, research shows that both green tea and Zoloft can affect blood thinning, and taking green tea with meds that have anticoagulation or blood-thinning effects is not recommended (4,5). 

Animal research models also show blood thinning after green tea consumption (4), and sertraline, the active ingredient in Zoloft can also cause blood thinning and is contraindicated to take with drugs, such as anticoagulants, NSAIDs, etc, as it can increase the risk of bleeding (1,5). 

Some research studies also indicate that green tea can reduce depression, and animal research models support this claim (6). It can be speculated that green tea might affect certain chemicals in your brain and does contain caffeine

Zoloft, being an antidepressant, can also affect your brain chemistry (1). So, taking the two together excessively can cause side effects, and some people could be more sensitive to such effects.

What are the potential effects of Zoloft and green tea interaction? 

The combination of Zoloft and green tea can cause the following side effects (1,2,7):

Gastrointestinal side effects

Both Zoloft and green tea may contribute to gastrointestinal discomfort, including side effects like nausea, stomach upset, or diarrhoea. Combining the two might increase the risk of experiencing these side effects. 

Blood thinning

Both Zoloft and green tea can have mild blood-thinning effects. While this is generally not a significant concern for most people, it’s important to be considered for those already taking medications that affect blood clotting or people with bleeding disorders. 

If you are on blood-thinning medications or have clotting concerns, it is important to discuss this interaction with your healthcare provider.

Increased Zoloft-induced side effects

Green tea can enhance some of the side effects associated with Zoloft, such as jitteriness, restlessness, or difficulty sleeping. This can affect patient compliance and people may not want to continue taking Zoloft – which can affect their treatment goals.

Can you drink green tea safely with Zoloft?

You can safely drink green tea while being treated with Zoloft if you drink in moderation. It is important to note that people have different factors affecting their health, so if you are someone with comorbidities, it’s best for you to avoid any combination that could potentially affect your health, including this one. 

However, if you are generally a healthy individual looking forward to enjoying a cup or two of green tea while taking Zoloft, you certainly can. However, you need to be careful about a few things:

  • The amount of green tea consumed
  • Other medications that you might be taking and their potential interactions with green tea or your Zoloft
  • The ingredients added to your green tea. Some may contain herbs, such as valerian root, St. John’s Wort, or grapefruit flavouring, which should not be consumed with Zoloft.
  • Underlying health conditions – like bleeding disorders, etc.

As long as you don’t have the above-mentioned things to worry about, you can safely consume the two together – but again, excessive intake can affect your health.

What to do if you feel unwell after drinking green tea with Zoloft?

If you have consumed green tea with Zoloft and you feel unwell, please reach out to your healthcare provider. The combination may not cause life-threatening complications, but people are different and can respond differently to such combinations. 

If you’re someone with a bleeding disorder, this combination can prolong bleeding time or cause other side effects. Additionally, green tea can increase the risk of Zoloft-induced side effects, which can affect your treatment goals as your body will take longer to adjust to the antidepressant. 

So, make sure you discuss these points with your provider and talk about the basic dos and don’ts while taking Zoloft. 

As a pharmacist, I have seen people enjoying green tea while being treated with an antidepressant but have also seen people struggling with this. The same goes for caffeinated beverages, as sertraline can potentially interact with those as well. 

However, you can still enjoy these beverages with Zoloft if you stick to the recommended amounts and do not exceed them. It is also important to consider other factors to ensure your safety.


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  1. D’Alessandro C, Benedetti A, Di Paolo A, Giannese D, Cupisti A. Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review. Nutrients. 2022 Jan 4;14(1):212. doi: 10.3390/nu14010212. PMID: 35011087; PMCID: PMC8747252. 
  1. Chen XQ, Wang XB, Guan RF, Tu J, Gong ZH, Zheng N, Yang JH, Zhang YY, Ying MM. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct. 2013 Oct;4(10):1521-5. doi: 10.1039/c3fo60088b. PMID: 24056410. 
  1. Eslami Shahrbabki M, Eslami Shahrbabaki A. Sertraline-related bleeding tendency: could it be dose-dependent? Iran J Psychiatry Behav Sci. 2014 Fall;8(3):81-3. PMID: 25780379; PMCID: PMC4359729. 
  1. Zhu WL, Shi HS, Wei YM, Wang SJ, Sun CY, Ding ZB, Lu L. Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol Res. 2012 Jan;65(1):74-80. doi: 10.1016/j.phrs.2011.09.007. Epub 2011 Sep 22. PMID: 21964320. 
  1. Khan N, Mukhtar H. Tea and health: studies in humans. Curr Pharm Des. 2013;19(34):6141-7. doi: 10.2174/1381612811319340008. PMID: 23448443; PMCID: PMC4055352. 

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