Celexa and Buspar: Is there any interaction? 

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In this blog post, we are going to talk about the possible interactions between celexa and buspar. Celexa is an antidepressant which is used to treat a variety of mental health conditions. 

This antidepressant can interact with other prescription medications as well, which may make the treatment unbearable. This blog will cover the safety and efficacy of the concomitant use of celexa and buspar. 

Is there any interaction between Celexa and Buspar? 

Celexa and Buspar may interact with each other and increase the risk of serotonin syndrome, which is the condition associated with too much serotonergic activity. Experts suggest that these two medicines should be used at low doses if they are used together. 

However, monotherapy with either celexa or buspar is considered safe and effective for the treatment of depression and anxiety. Serotonin syndrome is associated with the following signs and symptoms:

  • Excessive sweating 
  • Fever with chills
  • Restlessness and fatigue
  • Headache, which often feels like your head is pounding
  • Changes in blood pressure and/or temperature
  • Nausea
  • Vomiting
  • Diarrhoea
  • Bradycardia
  • Tremors
  • Muscle twitching and muscle pain
  • Shivering and goosebumps
  • Mental confusion 

Make sure you ask your healthcare provider before you start using any medication. It is not recommended to self medicate.

However, if your doctor has prescribed the medications together then you should take them in the best possible way in order to maximise the benefits and minimise the side effects or any possible interaction. 

Several studies have indicated that the combined treatment of celexa and buspar is a good option to cure treatment resistant generalised anxiety disorder (GAD). 

However, a 2001 study indicated that this combination drugs can not only interact with each other, but also with other medications. The concomitant use can interact with analgesics and can significantly reduce the pain killer action of such meds. 

It is recommended to use painkillers with caution when you’re on the combination treatment of celexa and buspar. Another study included a case study which showed signs of serotonin syndrome while being on the combination treatment.

Several other researchers revealed that this combination can not only cause serotonin syndrome, but can also dangerously lower the amount of sodium in your body, a condition called Hyponatremia. 

This is also associated with mental confusion, arrhythmia, forgetfulness and impaired motor coordination. Make sure you use this combination only if your healthcare provider has prescribed it. 

What is Celexa and how does it work? 

Celexa, brand name for Citalopram, is a selective serotonin reuptake inhibitor (SSRI). It works by inhibiting the reuptake of serotonin from the synaptic cleft back to the presynaptic neuron, which released this excitatory neurotransmitter in the first place. 

Celexa does that by blocking serotonin transporters (SERT) which are responsible to move serotonin back into the neuron. This results in increased amounts of active serotonin in your body which binds to its respective receptors present throughout the body. 

Serotonin is a neurotransmitter responsible for modulating mood, cognition, reward, learning, memory, and various other psychological processes. 

Celexa is not just used for the treatment of anxiety and depression, but it is also used to treat several other mental health conditions including obsessive compulsive disorder (OCD), social anxiety disorder (SAD), post-traumatic stress disorder (PTSD), eating disorders and premenstrual dysphoric disorder (PMDD). 

What is Buspar and how does it work? 

Buspar, brand name for Buspirone, is an anti-anxiety medication. Its mechanism of action is completely different from other anxiolytics including benzodiazepines, Barbiturates and selective serotonin reuptake inhibitors (SSRIs). 

Buspirone is a non-benzodiazepine azapirone and acts by working on the neurotransmitters in your brain. It is believed to be a serotonin receptor agonist which works on 5-HT1 receptors. 

Buspar is considered a good option and can be used for the treatment of generalised anxiety disorder (GAD), which is resistant to other treatment options. 

Experts believe that buspar also increases the amounts of norepinephrine and dopamine and can make the reward pathway more pronounced, which not only makes you feel happy and relaxed, but also relieves the physical symptoms of anxiety. 

It can be used in combination with antidepressants, but doses should be appropriate in order to prevent harmful side effects.

What are the side effects associated with the use of celexa and buspar? 

Both celexa and buspar are associated with some side effects that can range from mild to severe depending on the tolerability of the person taking it. 

Experts suggest that side effects have a close relationship with the way your body responds when it gets exposed to one or the combination of meds. Preexisting health conditions can also play a huge role in determining the kind of side effects the meds will cause in you. 

Make sure you inform your healthcare provider if you exhibit any sign of an allergic reaction or any other unusual side effect. The most common side effects of celexa include:

  • Nausea 
  • Vomiting 
  • Diarrhoea or Constipation 
  • Acid reflux or heartburn 
  • Abdominal pain 
  • Loss of appetite 
  • Weight gain or loss 
  • Excessive sweating or night sweating (nocturnal/night hyperhidrosis) 
  • Frequent urination 
  • Polydipsia or excessive thirst
  • Tremors 
  • Muscle twitching and pain
  • Drowsiness 
  • Dizziness 
  • Excessive tiredness or fatigue 
  • Insomnia or inability to fall asleep 
  • Xerostomia or dry mouth 
  • Dysmenorrhea or heavy periods
  • Flu like symptoms including irritation in eyes and runny nose
  • Loss of libido in both male and females. Males may suffer from inability to ejaculate, while females may suffer from inability to have an orgasm. 

Celexa (Citalopram) is also associated with some serious side effects, which may include:

  • Allergic reaction associated with symptoms like redness of skin, itching, burning sensation, blisters, blue-purple patches, tightness of chest, wheezing, difficulty in breathing, hoarseness etc. 
  • Auditory or visual hallucinations 
  • Nose bleeds
  • Severe headache
  • Arrhythmia or abnormal heartbeats
  • Impaired memory and concentration 
  • Convulsions 
  • Swelling or tenderness in different parts of the body.

Buspar is also associated with some side effects, which may include:

  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Abdominal pain 
  • Dizziness 
  • Drowsiness 
  • Fatigue 
  • Tiredness or confusion
  • Excitement 
  • Insomnia or inability to fall asleep 
  • Headaches 
  • Tingling and numbness
  • Excessive sweating 

Serious side effects include:

  • Allergic reaction associated with symptoms like redness of skin, itching, burning sensation, blisters, blue-purple patches, tightness of chest, wheezing, difficulty in breathing, hoarseness etc. 
  • Convulsions 
  • Swelling or tenderness in different parts of the body.
  • Blurred vision 

How to ensure the proper use of celexa and buspar? 

Immediately talk to your healthcare provider if you experience unusual side effects while taking celexa and buspar together. Do not recommend this combination to someone else and use it as long as your doctor has advised. 

Inform your doctor if you’re pregnant or trying to conceive. It is extremely important to ensure safety of your meds during your pregnancy. Some meds can cross placenta and are capable of causing unwanted side effects in the growing fetus. 

Inform your doctor if you’re a breastfeeding mother. Both of these drugs are capable of passing into the breastmilk and may cause side effects in newborns. 

Celexa may induce suicidal behavior in users younger than 24 years of age. If you have someone who shows suicidal behavior or you see hopelessness in them, make sure you keep an eye on them and get medical attention as soon as you can. 

Do not stop celexa and buspar abruptly. If it’s time for you to stop one or both of these meds, your doctor will simply recommend a taper schedule for you, which should be followed vigilantly if you wish to keep withdrawal symptoms at bay. 

Conclusion 

In this blog post, we have discussed the possible interactions between celexa and buspar. Celexa and Buspar may interact with each other and increase the risk of serotonin syndrome, which is the condition associated with too much serotonergic activity. 

Experts suggest that these two medicines should be used at low doses if they are used together. However, monotherapy with either celexa or buspar is considered safe and effective for the treatment of depression and anxiety. 

Make sure you ask your healthcare provider before you start using any medication. It is not recommended to self medicate. This combination can not only cause serotonin syndrome, but can also dangerously lower the amount of sodium in your body, a condition called Hyponatremia.

This is also associated with mental confusion, arrhythmia, forgetfulness and impaired motor coordination. Make sure you use this combination only if your healthcare provider has prescribed it. 

FAQs: celexa and buspar 

Is it OK to take Celexa and Buspar together?

Yes, it is okay to take celexa and buspar together but only if it is prescribed by your healthcare provider. Celexa and Buspar may interact with each other and increase the risk of serotonin syndrome, which is the condition associated with too much serotonergic activity. 

Can Buspar be taken with an SSRI?

Buspar can be taken with an SSRI. Experts suggest that these two medicines should be used at low doses if they are used together. However, monotherapy with either an SSRI or buspar is considered safe and effective for the treatment of depression and anxiety. 

How quickly does buspirone work for anxiety?

Buspar, brand name for Buspirone, is an anti-anxiety medication. Its mechanism of action is completely different from other anxiolytics including benzodiazepines, Barbiturates and selective serotonin reuptake inhibitors (SSRIs). Buspirone is a non-benzodiazepine azapirone and acts by working on the neurotransmitters in your brain. It is believed to be a serotonin receptor agonist which works on 5-HT1 receptors. 

What medications should not be taken with BuSpar?

  • Monoaminoxidase inhibitors (MAOIs). The combination use can increase the risk of serotonin syndrome. 
  • Non-steroidal anti-inflammatory drugs (NSAIDS). The combination use can increase the risk of bleeding. 
  • Pimozide. The concomitant use can increase the plasma concentration(availability of a drug in the blood) of pimozide to much higher levels. It can result in life-threatening arrhythmia.
  • Controlled substances, including all narcotic analgesics. The concomitant use can cause severe psychological side effects. 
  • Mood stabilisers 
  • Alcohol 

What is the first drug of choice for anxiety?

Both benzodiazepines and selective serotonin reuptake inhibitors (SSRIs) are used as a first line of agents for the treatment of anxiety. However, it depends on the severity of your condition and how well you tolerate these drugs. 

Can you take buspirone as needed for anxiety?

No, buspar should be used properly in order to work. Just like SSRIs, buspar starts to work within 4 to 6 weeks. So, it should not be used as needed. 

References 

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