Can Zoloft cause poor circulation? (3 factors involved)

Can Zoloft cause poor circulation?

No, Zoloft does not typically cause poor circulation. It is not a commonly reported side effect, and people who may experience it may have different underlying factors leading up to it. Zoloft, also known as sertraline, is a selective serotonin reuptake inhibitor commonly used for depression and anxiety (1,2). 

This antidepressant does not affect your vessels or their ability to carry blood through your body. However, people are different and can respond to medications differently. 

Genetic variations play a huge role, and some people could respond negatively to Zoloft due to drug sensitivity. If you think Zoloft is affecting your circulation because of numbness in your hands or feet, it is a common side effect and is not typically linked to poor circulation.

What does research suggest?

Research studies have not found a proper link between Zoloft and poor circulation. This side effect was not reported in the clinical trials and is not listed as a common side effect. (3)

Some research studies have indicated that Zoloft can affect vessels to some extent but can cause vasodilation, which is why it can be used by cardiac patients (4). However, there is no research study or case reports that explain poor circulation associated with sertraline. 

However, it is important to note that people can have different factors affecting their health. These factors can play a huge role and create diversity. Not everyone experiences the same side effects on Zoloft or any other medication; so it’s best to talk to your doctor about your concerns.

What factors can affect circulation while taking Zoloft?

Several factors can affect circulation while taking Zoloft:

Individual sensitivity

Some individuals could be sensitive to the effects of Zoloft and may react differently to this medication. Poor circulation is not something commonly reported with Zoloft, but people who are hypersensitive to this medication may experience it.

Underlying health conditions

Some underlying health conditions can affect circulation or cause poor circulation that could be completely unrelated to the medication. Some conditions that can affect circulation include:

Health conditionsPotential impact on circulation
Mild varicose veinsSwollen and twisted veins often cause discomfort but not severe circulatory issues.
ObesityExcess weight can contribute to circulatory issues.
AnaemiaReduced red blood cell count can impact circulation.
HypertensionIncreased pressure in arteries, affecting overall circulation.
AtherosclerosisConditions like high cholesterol or diabetes contribute to arterial plaque buildup.
Autoimmune disordersThe initial impact on blood vessels may affect circulation.
DiabetesHigh blood sugar levels can damage blood vessels and affect circulation.

Use of other medications

Zoloft may cause unusual or uncommon side effects when taken with other medications that could potentially affect your health. So, if you’re taking Zoloft with any other drug that can cause poor circulation, you may experience this side effect. Some meds which can impact circulation include:

Medications Potential impact on circulation
VasoconstrictorsConstrict blood vessels, potentially limiting blood flow.
Hormone Replacement Therapy (HRT)May impact blood clotting and cardiovascular function.
AntipsychoticsSome may have cardiovascular side effects impacting circulation.
ImmunosuppressantsCan impact blood vessel function and circulation.

What to do if Zoloft affects circulation?

If you think Zoloft is affecting your circulation, it’s important to reach out to your doctor. Your provider will determine the exact cause of poor circulation and will rule out other potential factors that could affect it. 

If there is an underlying cause, unrelated to Zoloft, that is affecting your blood circulation, your doctor will adjust your treatment plan accordingly to manage all of your symptoms. If Zoloft is solely affecting your circulation or you’re sensitive to the effects of this medication, your doctor will consider alternative treatment options. 

It’s common for people to try multiple antidepressants before they find the one that works best for them. So if Zoloft is causing side effects, don’t worry! Your doctor will take care of you and will help manage your symptoms.

Effects of Zoloft on blood flow

In my experience as a pharmacist, I have never come across a patient with circulation issues while taking Zoloft. However, such cases have been rarely reported in the literature, and different factors can play important roles in contributing to them. 

So it’s best to report your concerns to your doctor to determine the root cause of your circulation issues and the proper management. This is important to ensure the safe and effective use of medications and the improvement of your overall physical and mental health.


  1. Singh HK, Saadabadi A. Sertraline. 2023 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31613469. Available from:
  1. The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. ZOLOFT (sertraline hydrochloride) tablets, for oral use. Available from:
  1. National Library of Medicine. Sertraline: MedlinePlus Drug Information [Internet]. Bethesda (MD): U.S. National Library of Medicine. Available from:
  1. van Melle JP, Buikema H, van den Berg MP, van Buiten A, van Veldhuisen DJ, Boonstra PW, van Gilst WH. Sertraline causes strong coronary vasodilation: possible relevance for cardioprotection by selective serotonin reuptake inhibitors. Cardiovasc Drugs Ther. 2004 Nov;18(6):441-7. doi: 10.1007/s10557-004-6221-3. PMID: 15770431. 

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