Can mirtazapine cause anger? (5+ ways to get rid of it)

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In this blog post, we are going to answer the question, “Can mirtazapine cause anger?”. Mirtazapine is an antidepressant which is used to treat a number of mental health related problems. 

However, this medicine is associated with some side effects including anger and aggression. This blog will cover why mirtazapine causes anger and what can be done to manage it. 

Can mirtazapine cause anger? 

Yes, mirtazapine can cause anger issues in some individuals. This medication is associated with a lot more mood and behavioural changes that have been reported by people for more than a decade. 

Several case studies have shown people with erratic behaviour and violence after taking mirtazapine for a few weeks. Such people have also shown signs of other behavioural changes like anxiety and irritability. 

Experts believe that the main cause of the anger is the mechanism of action of mirtazapine. As the drug alters the amounts of neurotransmitters in your brain, it can lead to different behavioural changes in people. 

Some people get so angry that they start throwing things around or simply start hitting people. This effect was monitored by researchers in many individuals and it was seen that they were triggered by even the slightest inconvenience. 

It was found more common in people with aggressive personalities. However, one survey revealed a woman in her mid-30s, who has always been calm and friendly. She started mirtazapine to get rid of her chronic depression, but the drug changed a number of things in her. 

Her close friends and family revealed that soon after she started her treatment with mirtazapine, she started to flip out on literally everything. She was always angry, moody and irritated. 

Experts looked into her case and once again, they blamed the drug’s mechanism of action for causing this side effect. Mirtazapine is an antidepressant.

It does not belong to any typical class of antidepressants and its mechanism of action is different from SSRIs and SNRIs. It does not block the reuptake of serotonin by any pathway. 

Mirtazapine (Remeron) belongs to the tetracyclic antidepressants. It has a dual mode of action. Mirtazapine is believed to be responsible for the activation of 5-HT1 receptors, which are one of the serotonin receptors. This antidepressant also acts on the noradrenergic system. 

Experts believe that remeron enhances the stimulatory action of the noradrenergic system which increases the secretion of serotonin. It also prevents the inhibitory action of the noradrenergic system which hinders the release of serotonin. 

This way, it actively increases the amount of this excitatory neurotransmitter in your system. Mirtazapine can be used to treat the following health conditions:

  • Depression 
  • Anxiety 
  • Treatment resistant depression 
  • Depression in elderly patients
  • Post-operative nausea
  • Alcohol dependence
  • Insomnia or inability to fall asleep 
  • Neuropathic pain
  • Inability to feel hungry/hunger suppression

It is impossible to predict how your body will react once it is exposed to this medication. Every single individual shows different signs and there is no way to set a standard for the side effects of mirtazapine. 

It is usually not tolerated well in many individuals and the drug can cause serious complications in some people. Mood related side effects can make you feel the worst. 

This is because your brain controls everything in your body, every system. Be it happiness, sadness, thirst or hunger, all is controlled by your brain. When your brain is affected, all of the other things are compromised. 

Is there any way to get rid of mirtazapine induced anger? 

There are a few ways that may help you with your anger management. These include:

Talk to your healthcare provider 

First thing’s first, talk to your doctor. If mirtazapine makes you angry and you start to experience real consequences because of that anger, this indicates that this medication is messing up with your brain. Your doctor will make sure if you’re on the right dose. 

Sometimes, the dose is too high and people can’t seem to tolerate it well and keep complaining of disturbing side effects. If your anger keeps progressing and you feel like you have turned into someone you’re not, you may need to discontinue the treatment with mirtazapine. 

However, it is advised not to stop your mirtazapine without your doctor’s approval, especially if you have been on a high dose. Mirtazapine withdrawal syndrome is real and can affect people who are on higher doses. 

Maintain good sleep hygiene 

People who are sleep deprived are more likely to suffer from anger and agitation caused by mirtazapine. If you continue to sleep well, it may make positive changes in your brain. Several studies suggest that when you sleep well at night, you wake up with a better mood and better energy levels. 

Centers for disease Control and Prevention (CDC), suggests following tips to make your sleep quality better than it is now. These include:

  • Try to go to bed at the same time every day, working days as well as weekends. 
  • Make sure your bedroom is always quiet, dark, relaxing, and at a comfortable temperature to help you relax and make your sleep quality better.
  • Do not use electronic devices or gadgets before going to bed. They reduce your sleep quality. Make sure you remove such devices from your room or switch them off.
  • Avoid large meals, caffeine, and alcohol before bedtime. They will only ruin your sleep quality.
  • Stay active. Exercise can help relax your muscles and make your sleep quality better.

Stay active

Staying active is the best way to fight against anger. Make sure you workout at least 3 to 4 times a week. Exercise releases happy chemicals in your brain. It not only makes you feel good, but also spikes your energy levels and elevates your mood. 

Morning workout is considered most efficient in head-starting your day. Go for a walk or do 10 minutes of high intensity interval training (HITT). It not only helps you to overcome anger caused by mirtazapine, but it also makes your body healthy, like actually healthy. 

Some of the best exercises to increase energy levels include:

  • Yoga
  • Pilates
  • Tai Chi
  • Resistance strength training

Stay hydrated 

Drink plenty of water. Water clears out toxins from your body. Try making a detox water by adding your favourite fruits in it. You can add lemon, cucumber, kiwi, oranges, berries, ginger etc, to make drinking water less boring. 

This will not only add taste, but also makes your water nutritious and full of antioxidants. 

Absorb and radiate positive energy 

Try to keep your mind on the positive side. Studies suggest happiness and positivity increase elevates your mood and tones down your anger. When your brain absorbs positivity, it releases energy. 

So, always surround yourself with people who deal with you positively, people who are supportive and fill you up with optimism and people who make you look at the brighter side. 

Make time for fun activities 

Always have time for fun activities. Engage in activities which make you feel alive. For some people, it’s simply spending quality time with their friends and family. 

You can watch a funny movie, change your hairstyle, change your routine, have a weekend away, go hiking, etc. Do not pack yourself up with work and daily life activities. Always have some time to take everything off of your shoulders. Trust me, it’s worth it! 

Limit alcohol and caffeine 

Caffeine can affect your sleep by keeping you awake for a longer period of time and can make you angry and anxious the next day. The Food and Drug Authority (FDA) recommends no more than 400 milligrams (about four or five cups of coffee) per day. 

In addition, caffeine’s half-life can range from 2-12 hours, so try to avoid drinking coffee or any other caffeinated beverage within six hours of bedtime or else you’ll stay awake and the night will become unbearable for you. 

Alcohol, on the other hand, is the biggest enemy when you’re on mirtazapine or any other antidepressant. These meds and alcohol never do well together. 

The combination not only enhances the side effects of mirtazapine, but causes a number of more disturbing complications. Make sure you cut back on alcohol as much as you can while you’re being treated with mirtazapine, or any other antidepressant. 


In this blog post, we have discussed mirtazapine induced anger. Mirtazapine is used for a number of conditions. However, this antidepressant can cause a number of side effects including anger and irritability. The drug can also cause significant mood swings without a valid reason. 

It can also cause depression, sadness and suicidal behavior. These mood fluctuations are most probably linked to the mechanism of action of mirtazapine. The drug increases the amount of some excitatory neurotransmitters in your brain that may make people act differently. 

Any drug that can alter the amounts of neurotransmitters in your brain can make behavioural changes in you. Make sure you are not using any other medication that might interact negatively with mirtazapine or enhance its side effects. 

FAQs: mirtazapine side effects anger

Can mirtazapine cause mood swings?

Yes, mirtazapine can cause mood swings. The med can make you angry and agitated. It can cause significant mood swings without a valid reason. It can also cause depression, sadness and suicidal behavior. These mood fluctuations are most probably linked to the mechanism of action of mirtazapine. 

Does mirtazapine help with anger?

Mirtazapine is not a drug for anger management. It is an antidepressant which is used to treat mild to severe episodes of depression and anxiety. However, if your anger or any other behavioural change is triggered by your mental health condition that can be treated by mirtazapine then the drug may help you with your anger. 

Can mirtazapine make you psychotic?

Mirtazapine may induce the symptoms of psychosis. Several surveys have revealed that mirtazapine can make people behave angrily and erratically. This may be due to the mechanism of action of mirtazapine. Any drug that can alter the amounts of neurotransmitters in your brain can make behavioural changes in you.

What are the most common side effects of mirtazapine?

  • Sleepiness or drowsiness 
  • Excessive tiredness or fatigue 
  • Dizziness or lightheadedness 
  • Xerostomia or dry mouth 
  • Anxiety 
  • Agitation 
  • Confusion 
  • Gain of appetite
  • Weight gain 
  • Gastrointestinal side effects including nausea, vomiting and diarrhoea/Constipation 

Can antidepressants make you mean or angry?

Antidepressants may make you mean or angry by disturbing the levels of neurotransmitters in your brain. This side effect can vary from person to person. It is impossible to predict how your body will react once it is exposed to this medication. 


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