Can I take Tylenol with Prednisone? (A Brief Guide)


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Page last updated: 15/10/2022

Can I take Tylenol with Prednisone?

In this guide, we will answer the question “Can I take Tylenol with Prednisone?”, what is Tylenol, what is prednisone, side effects of prednisone, precautions before taking prednisone among other things to consider. 

Can I take Tylenol with Prednisone?

To answer the question “Can I take Tylenol with prednisone?” we have to take into account that even if no interactions have been found between Prednisone and Tylenol (acetaminophen), this doesn’t mean no interaction exists.

You should always contact your healthcare provider for additional information and advice before starting to take both medicines.

Prednisone is a drug classed as a glucocorticoid known under the brand names Sterapred, Sterapred DS and Prednisone Intensol.

According to it is used to treat conditions such as:

  • Acute lymphocytic Leukemia
  • Adrenocortical Insufficiency
  • Adrenogenital Syndrome
  • Allergic Reactions
  • Allergic Rhinitis
  • Ankylosing Spondylitis
  • Aspiration Pneumonia
  • Keratitis
  • Psoriasis
  • Systemic Sclerosis
  • Herpes Zoster
  • Eczema
  • Sarcoidosis
  • Synovitis
  • Sinusitis
  • Scleroderma
  • Inflammatory Conditions
  • Inflammatory Bowel Disease

Here are just some of the conditions Prednisone is used to treat, however, click here if you want to see the rest of the conditions. 

In contrast, Tylenol (acetaminophen) is classed as a miscellaneous analgesic and it is used to treat fever, pain, muscle pain, and Sciatica.

Can I take Tylenol with Prednisone? (A Brief Guide)

Prednisone: What do I need to know?

According to the Mayo Clinic, Prednisone provides relief for areas of the body that are inflamed.

As we mentioned earlier, it is used to treat a number of conditions and it works on the immune system to help relieve swelling, redness, itching and allergic reactions.

It is available in the following dosage forms: tablets, solution, and tablets with delayed-release. 

Before using Prednisone, it is important to consider the risks of taking this medicine.

This is a decision that your doctor and you need to make, considering the following:


If you have had an allergic reaction to this medicine or any other medicine, you should tell your doctor.

Additionally, it is advised to tell your doctor if you have any other allergies such as foods, dyes, preservatives or animals, and remember to read the label to know about the active ingredients.


Some studies suggest there are no problems related to pediatric uses.

However, children may be more likely to have slower growth and bone problems if this medicine is administered long-term.

The recommended doses shouldn’t be exceeded and children should be monitored during treatment.


Some studies suggest there are no specific problems related to geriatric use.

However, elderly patients require an adjusted dose since they are more prone to having kidney, liver or heart problems.

Pregnancy and breastfeeding

Some studies in pregnant women have shown a risk for the fetus, however, if there is a life-threatening situation or a serious disease, the benefits of taking prednisone may outweigh the potential risks.

Additionally, breastfeeding is considered safe and studies suggest that it poses minimal risk for the infant.

Drug interactions for prednisone

When taking prednisone it is important to discuss with your doctor about the potential interaction of prednisone with any other drug you may be taking.

According to the Mayo Clinic using prednisone with any of the following medicines is not recommended:

  • Desmopressin
  • Rotavirus Vaccine, Live

Additionally, the following medicines are not recommended to use when taking prednisone but in some cases, it may be required and your doctor will probably make adjustments to the doses and how often you use the medicines. 

  • Aceclofenac
  • Acemetacin
  • Aldesleukin
  • Alfentanil
  • Amtolmetin Guacil
  • Asparaginase
  • Balofloxacin
  • Bemiparin
  • Benzhydrocodone
  • Besifloxacin
  • Bromfenac
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Celecoxib
  • Ceritinib
  • Choline Salicylate
  • Ciprofloxacin
  • Clonixin
  • Codeine
  • Daclatasvir
  • Darunavir
  • Desogestrel
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Dienogest
  • Diflunisal
  • Dihydrocodeine
  • Dipyrone
  • Dronedarone
  • Drospirenone
  • Droxicam
  • Elvitegravir
  • Enoxacin
  • Estradiol
  • Ethinyl Estradiol
  • Ethynodiol
  • Etodolac
  • Etofenamate
  • Etonogestrel
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fleroxacin
  • Floctafenine
  • Flufenamic Acid
  • Flumequine
  • Flurbiprofen
  • Gatifloxacin

This is a short list of medicines but if you would like to check if any of the current medicines you are taking can potentially interact with prednisone click here.

Warnings of taking Prednisone

  • According to Everyday Health, prednisone can make it harder for your immune system to fight infections and if you do indeed get an infection it may not develop with the typical symptoms. The reason why, while taking prednisone it is important to avoid coming in contact with people who have chickenpox or measles.
  • Additionally, to fight any viruses it is important to wash your hands often and take other precautions to keep you away from the risk of being sick.
  • As we have discussed, for children taking prednisone, they may have slow growth and development. Make sure to discuss this with your doctor before starting the treatment. 
  • Also, prednisone can increase the risk of developing osteoporosis, making your bones fragile and at a higher risk for fractures so it is important to take precautions to protect your bone health. 
  • Prednisone has been associated with the risk of developing a type of cancer called Kaposi’s sarcoma. This manifests with the development of abnormal tissue under the skin in the lining of the mouth, nose, and throat. 
  • If you have had threadworms, it is important to tell your doctor. 
  • If you have diabetes, high blood pressure, emotional problems, mental illness, seizures, tuberculosis, ulcers, and a thyroid condition, to name a few, you need to tell your doctor about your current medical history before taking prednisone.

Prednisone Side effects

Like any other medicine, Prednisone comes with the risk of developing some of the following common side effects (Everyday Health and Mayo Clinic): 

  • Headache
  • Aggression
  • Dizziness
  • Trouble sleeping
  • Inappropriate happiness
  • Severe mood swings
  • Personality change
  • Bulging eyes
  • Acne
  • Thin, fragile skin
  • Red or purple blotches or lines under the skin
  • Slowed healing of cuts and bruises
  • Increased body hair growth
  • Changes in the way fat gets distributed in the body
  • Extreme tiredness
  • Weak muscles
  • Irregular or absent menstrual periods
  • Low sex drive
  • Heartburn
  • Unusual sweating
  • Aggression
  • agitation
  • blurred vision
  • A decrease in the amount of urine
  • dizziness
  • fast, slow, pounding, or irregular heartbeat or pulse
  • headache
  • irritability
  • mood changes
  • noisy, rattling breathing
  • numbness or tingling in the arms or legs
  • pounding in the ears
  • shortness of breath
  • swelling of the fingers, hands, feet, or lower legs
  • trouble thinking, speaking or walking
  • troubled breathing at rest
  • weight gain

Incidence not known

  • abdominal or stomach cramping or burning (severe)
  • abdominal or stomach pain
  • Backache
  • bloody, black, or tarry stools
  • cough or hoarseness
  • darkening of the skin
  • A decrease in height
  • decreased vision
  • Diarrhea
  • dry mouth
  • eye pain
  • eye tearing
  • facial hair growth in females
  • Fainting
  • fever or chills
  • flushed, dry skin
  • Fractures
  • fruit-like breath odor
  • full or round face, neck, or trunk
  • heartburn or indigestion (severe and continuous)
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • loss of sexual desire or ability
  • lower back or side pain
  • menstrual irregularities
  • muscle pain or tenderness
  • muscle wasting or weakness
  • Nausea
  • pain in the back, ribs, arms, or legs
  • painful or difficult urination
  • skin rash
  • trouble sleeping
  • unexplained weight loss
  • unusual tiredness or weakness
  • vision changes
  • Vomiting
  • vomiting of material that looks like coffee grounds

If you notice some of the side effects or any other side effects not listed it is important to contact your health care provider or your physician for advice. 

Prednisone Dosage

As mentioned before the available presentations of prednisone can be as tablets, liquid and concentrated liquid that can include 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and 50 mg.

Prednisone and alcohol 

It is not recommended to mix prednisone with alcoholic beverages since there is existing evidence that it may increase the risk of developing liver, gastrointestinal, kidney problems, and other health conditions. 

Prednisone Overdose

An overdose with corticosteroids is considered dangerous and can derive in the following symptoms (Everyday Health):

  • Burning or itching skin
  • Convulsions
  • Deafness
  • Depression
  • Dry skin
  • High blood pressure
  • Muscle weakness
  • Nervousness
  • Psychosis
  • Sleepiness
  • Missed menstrual cycle
  • Swelling in lower legs, ankles, or feet
  • Weakness
  • Worsening of health conditions such as ulcers or diabetes

If you or someone you know has overdosed on prednisone it is crucial to find medical assistance by calling emergency services or going to a hospital. 

What happens if I stop taking prednisone?

According to, even if you feel well already, it is not recommended to stop prednisone without consulting with our doctor first.

Stopping abruptly may prevent your body from having enough natural steroids to function properly.

This is said to lead to symptoms such as feeling the fatigued, weak, upset stomach, weight loss, and even mouth sores. 

Why is this blog about “Can I take Tylenol with Prednisone” important?

We have answered the question “Can I take Tylenol with Prednisone?” as we found no major reported interactions, however, it doesn’t mean they are non-existent.

It is important to always discuss with your doctor any type of medicine you are considering taking along while you are taking prednisone. 

Additionally, we have discussed the uses of prednisone, side effects, some precautions/warnings before starting the treatment, among other things to consider when taking prednisone. 

Please feel free to comment in the comments section below!

Frequently Asked Questions (FAQs) about “Can I take Tylenol with Prednisone”

Can you take Advil or Tylenol with prednisone?

Taking prednisone and ibuprofen can increase the probability of having side effects in the gastrointestinal tract (e.g inflammation, bleeding, ulceration and in rare cases perforation).

What should you not eat when taking prednisone?

When taking prednisone it is important to have a diet that avoids processed, canned and prepacked foods but includes fresh or frozen produce, low or non-fat dairy products, whole grains, seafood, and poultry. 

Can I take Tylenol with azithromycin?

There are no known interactions between azithromycin and Tylenol, however, this doesn’t mean there are no interactions at all.

It is important to consult and get advice from your physician. 

How quickly does prednisone work?

It is said that prednisone works very quickly (1 to 4 days) if the dose is adequate to be able to reduce the level of inflammation.

For some people even, they can start noticing effects after the first dose. 

Does prednisone help with pain?

Prednisone is a steroid medication prescribed to help with pain and acute flare-ups in inflammation but it must be used with precaution, especially when used long term. 


Mayo Clinic